INT325303

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDC) small molecule metabolic process (DDC) lyase activity (DDC)
cellular nitrogen compound metabolic process (DDC) cellular amino acid metabolic process (DDC) cytoplasm (DDC)
Anatomy Link Frequency
liver 2
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 42 95.96 Very High Very High Very High
Pain 10 46.72 Quite Low
Catechol-O-methyltransferase 16 45.84 Quite Low
Substantia nigra 16 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 166 90.96 High High
Pressure Volume 2 Under Development 6 89.68 High High
Vomiting 24 87.92 High High
Dyskinesias 94 76.76 Quite High
Injury 10 47.44 Quite Low
Tremor 12 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low
Dizziness 8 5.00 Very Low Very Low Very Low
Hypokinesia 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Approximately 70% of oral levodopa is metabolized by aromatic amino acid decarboxylase (AADC) in the intestinal mucosa and liver.
AADC Binding (metabolized) of in liver
1) Confidence 0.30 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915499 Disease Relevance 0.52 Pain Relevance 0.14
Approximately 70% of oral levodopa is metabolized by aromatic amino acid decarboxylase (AADC) in the intestinal mucosa and liver.
aromatic amino acid decarboxylase Binding (metabolized) of in liver
2) Confidence 0.30 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915499 Disease Relevance 0.52 Pain Relevance 0.14
The quinone structure of L-DOPA, which is covalently bound to the aldehydes on dextran/starch, can also react with amino groups of chitosan by an imine formation or a Michael adduct formation.
L-DOPA Binding (bound) of
3) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953395 Disease Relevance 0 Pain Relevance 0

General Comments

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