INT325312

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
arm 2
IL20 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 61 98.44 Very High Very High Very High
Inflammation 7 75.92 Quite High
cytokine 5 52.88 Quite High
chemokine 1 25.92 Quite Low
Arthritis 21 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Onset of action 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 69 98.44 Very High Very High Very High
INFLAMMATION 6 75.92 Quite High
Autoimmune Disease 1 41.28 Quite Low
Disease 13 38.16 Quite Low
Seronegative Spondarthritis 20 5.00 Very Low Very Low Very Low
Mycobacterial Infection 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further downstream, IL-20 and IL-22 have the ability to induce keratinocyte proliferation and epidermal remodeling through phosphorylation of Stat3, a transcription factor implicated in psoriasis.19,24 In contrast, IL-12 is associated with the Th1 arm.
IL-20 Positive_regulation (induce) of Phosphorylation (phosphorylation) of Stat3 in arm associated with psoriasis
1) Confidence 0.13 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.58 Pain Relevance 0.24

General Comments

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