INT325317

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) extracellular space (IL12A) extracellular region (IL12A)
nucleus (TH1L) cytoplasm (IL12A)
Anatomy Link Frequency
arm 1
IL12A (Homo sapiens)
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 61 99.60 Very High Very High Very High
Inflammation 7 83.92 Quite High
cytokine 5 45.08 Quite Low
chemokine 1 18.12 Low Low
Arthritis 21 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Onset of action 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 69 99.60 Very High Very High Very High
INFLAMMATION 6 83.92 Quite High
Disease 13 46.16 Quite Low
Autoimmune Disease 1 33.48 Quite Low
Seronegative Spondarthritis 20 5.00 Very Low Very Low Very Low
Mycobacterial Infection 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further downstream, IL-20 and IL-22 have the ability to induce keratinocyte proliferation and epidermal remodeling through phosphorylation of Stat3, a transcription factor implicated in psoriasis.19,24 In contrast, IL-12 is associated with the Th1 arm.
IL-12 Binding (associated) of Th1 in arm associated with psoriasis
1) Confidence 0.18 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.59 Pain Relevance 0.22

General Comments

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