INT32532

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Context Info
Confidence 0.61
First Reported 1987
Last Reported 2004
Negated 6
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.20
Pain Relevance 5.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
plasma 6
hypothalamus 4
blood 2
ARC 2
melanocyte 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 8 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
GABA receptor 1 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Catecholamine 1 99.84 Very High Very High Very High
Cannabinoid receptor 4 99.80 Very High Very High Very High
Pain 6 99.46 Very High Very High Very High
Cholecystokinin 8 99.32 Very High Very High Very High
Opioid 13 99.30 Very High Very High Very High
narcan 6 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 16 100.00 Very High Very High Very High
Hemorrhage 8 100.00 Very High Very High Very High
Aids-related Complex 2 99.88 Very High Very High Very High
Body Weight 3 98.00 Very High Very High Very High
Urological Neuroanatomy 1 77.12 Quite High
Pressure Volume 2 Under Development 2 76.08 Quite High
Eating Disorder 4 75.00 Quite High
Hypoalagesia 1 75.00 Quite High
Pain 1 73.24 Quite High
Lymphatic System Cancer 2 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased POMC mRNA levels did not affect the stress-induced POMC mRNA increase, measured following swim stress and restraint stress.
Neg (not) Regulation (affect) of Positive_regulation (increase) of POMC mRNA associated with stress
1) Confidence 0.61 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679057 Disease Relevance 0.58 Pain Relevance 0.39
The effect of GABA receptors agonists on the stress-induced beta-endorphin levels in the preoptic area and mediobasal hypothalamus of the intact and prenatally stressed male albino rats was studied.
Regulation (effect) of Positive_regulation (induced) of beta-endorphin in hypothalamus associated with stress, gaba receptor and agonist
2) Confidence 0.58 Published 2000 Journal Fiziol Zh Section Abstract Doc Link 10867869 Disease Relevance 0.16 Pain Relevance 0.26
Prazosin alone had no effect on the ether-induced plasma ACTH and beta-endorphin elevation.
Neg (no) Regulation (effect) of Positive_regulation (elevation) of beta-endorphin in plasma
3) Confidence 0.46 Published 1999 Journal Psychoneuroendocrinology Section Abstract Doc Link 10101737 Disease Relevance 0.42 Pain Relevance 0.66
It is suggested that while ejaculation may activate opioid receptor mechanisms, which affect the sensitivity to painful, but not sexual, stimuli, elevation of beta-endorphin in the blood does not affect the sensitivity to either sexual or painful stimuli in male rats.
Neg (not) Regulation (affect) of Positive_regulation (elevation) of beta-endorphin in blood associated with pain and opioid receptor
4) Confidence 0.44 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 2962014 Disease Relevance 0.15 Pain Relevance 0.75
It appears that ARC mRNA levels of proDyn, proEnk, and POMC are directly related to the amount of food consumed and/or changes in body weight in food-restricted and food-deprived rats.
Regulation (related) of Spec (appears) Positive_regulation (levels) of POMC in ARC associated with body weight and aids-related complex
5) Confidence 0.44 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8928900 Disease Relevance 0.66 Pain Relevance 0.24
Results indicated that AA rats had a significantly greater content of proopiomelanocortin mRNA in the arcuate nucleus of the hypothalamus, of proenkephalin mRNA in the prefrontal cortex and of prodynorphin mRNA in the mediodorsal nucleus of the thalamus (p < or = .05).
Regulation (had) of Positive_regulation (content) of proopiomelanocortin mRNA in hypothalamus associated with thalamus
6) Confidence 0.43 Published 2000 Journal Life Sci. Section Abstract Doc Link 10821116 Disease Relevance 0 Pain Relevance 0.51
The percentage of splenic NK cells (OX52+/CD5-) and T cells (CD5+/OX52-) was also unchanged by beta-endorphin treatment i.c.v.
Neg (unchanged) Regulation (unchanged) of Positive_regulation (treatment) of beta-endorphin in T cells
7) Confidence 0.39 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8795073 Disease Relevance 0.12 Pain Relevance 0.46
Intermediate lobe proDyn gene expression was not regulated by dopamine, in contrast to intermediate lobe POMC mRNA levels, which were increased with haloperidol and decreased with bromocriptine treatment, as expected.
Neg (not) Regulation (regulated) of Positive_regulation (increased) of POMC mRNA in lobe associated with dopamine
8) Confidence 0.38 Published 1993 Journal Endocrinology Section Abstract Doc Link 8243288 Disease Relevance 0 Pain Relevance 0.10
The potency of L-365,260 and L-364,718, selective CCK(B) and CCK(A) receptor antagonists, respectively, correlated with their apparent affinities for CCK(B) receptors, suggesting that the altered sensitivity to beta-endorphin is mediated via CCK(B) receptors.
Regulation (altered) of Positive_regulation (sensitivity) of beta-endorphin associated with antagonist, cholecystokinin and potency
9) Confidence 0.30 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10400222 Disease Relevance 0.30 Pain Relevance 1.21
Pre-treatment with naltrexone did not alter the time course or magnitude of the hemorrhage-induced increases in plasma beta-endorphin or catecholamines.
Neg (not) Regulation (alter) of Positive_regulation (increases) of beta-endorphin in plasma associated with catecholamine and cva
10) Confidence 0.09 Published 2001 Journal Shock Section Abstract Doc Link 11386621 Disease Relevance 0.81 Pain Relevance 0.72
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of delta(9)-tetrahydrocannabinol in rats.
Regulation (regulation) of Positive_regulation (increase) of adrenocorticotropin hormone in plasma associated with cannabinoid receptor and opioid
11) Confidence 0.07 Published 1999 Journal Brain Res. Section Title Doc Link 10482810 Disease Relevance 0 Pain Relevance 0.56
The role of cyclooxygenase inhibition in the effect of alpha-melanocyte-stimulating hormone on reactive oxygen species production by rat peritoneal neutrophils.
Regulation (role) of Positive_regulation (effect) of alpha-melanocyte-stimulating hormone in melanocyte
12) Confidence 0.05 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 15172677 Disease Relevance 0 Pain Relevance 0.07

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