INT325346

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (THPO) extracellular space (THPO) extracellular region (THPO)
Anatomy Link Frequency
platelet 2
THPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
Bioavailability 2 26.24 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 94 97.16 Very High Very High Very High
Cancer 2 84.88 Quite High
Pancytopenia 2 76.04 Quite High
Purpura 2 50.00 Quite Low
Heparin-induced Thrombocytopenia 4 40.72 Quite Low
Hemorrhage 24 5.16 Low Low
Fibrosis 10 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 10 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 10 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly elevated endogenous TPO levels have been observed in disorders in which there is diminished platelet production and therefore reduced TPO clearance, although thrombopoietin levels are typically normal in patients with ITP.
Negative_regulation (reduced) of Gene_expression (clearance) of TPO in platelet associated with thrombocytopenia
1) Confidence 0.43 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.10 Pain Relevance 0
However, clinical development of both recombinant TPOs was ultimately discontinued and many of the clinical studies undertaken between 1994 and 1999 remain unpublished.15

Alternative TPO agonists

Negative_regulation (unpublished.15) of Gene_expression (agonists) of TPO associated with agonist
2) Confidence 0.37 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.32 Pain Relevance 0.05

General Comments

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