INT325375

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53, PARP1) DNA binding (Tp53, PARP1) nucleus (Tp53, PARP1)
nucleolus (Tp53, PARP1) transcription factor binding (Tp53, PARP1) mitochondrion (Tp53)
Tp53 (Rattus norvegicus)
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 17 89.40 High High
Death 11 81.84 Quite High
Leukemia 4 80.96 Quite High
Genomic Instability 11 75.80 Quite High
Chromosome Aberrations 2 72.60 Quite High
Cancer 31 5.00 Very Low Very Low Very Low
Skin Cancer 10 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of relatively mild DNA damage, PARP-1 activation enhances DNA repair by interacting with p53 protein, signaling cell-cycle arrest, and facilitating DNA repair enzymes, including XRCC1 and DNA-dependent protein kinases to access damaged DNA [70].
p53 Binding (interacting) of Positive_regulation (enhances) of Positive_regulation (activation) of PARP-1
1) Confidence 0.05 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.59 Pain Relevance 0

General Comments

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