INT325390

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) signal transducer activity (Gpr39)
cytoplasm (Ghrl)
Anatomy Link Frequency
pituitary 1
Ghrl (Rattus norvegicus)
Gpr39 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 12 71.84 Quite High
antagonist 20 30.60 Quite Low
agonist 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 8 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obestatin was initially reported to be endogenous ligand for orphan G protein-coupled receptor GPR39 [2]; however recent studies have found no specific binding of obestatin to various types of GPR39-expressing cells [3–5].
obestatin Neg (no) Binding (binding) of GPR39-expressing
1) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0
Nevertheless, although binding of obestatin to the receptor GPR39 remains controversial, the functional effect of obestatin on gastrointestinal motility has been clearly demonstrated in our study.
obestatin Binding (binding) of GPR39
2) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0.05
However recent publications indicate that obestatin is unlikely to be the endogenous ligand for GPR39 on the basis of a lack of specific binding of obestatin to GPR39 receptor-expressing cells [2, 4, 5, 31].
obestatin Binding (binding) of GPR39
3) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0.06
GPR39 was initially proposed as the receptor for obestatin [2], and GPR39 expression has been detected in peripheral organs such as the duodenum and kidney but not in the pituitary or hypothalamus [4].
obestatin Binding (receptor) of GPR39 in pituitary
4) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0.07

General Comments

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