INT32541

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Context Info
Confidence 0.39
First Reported 1982
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.50
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
blood 2
plasma 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 7 99.48 Very High Very High Very High
dexamethasone 4 97.40 Very High Very High Very High
antagonist 4 95.00 High High
Serotonin 2 94.52 High High
opioid receptor 1 89.64 High High
fluoxetine 2 89.00 High High
Opioid 4 82.72 Quite High
agonist 1 62.08 Quite High
opiate 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 3 100.00 Very High Very High Very High
Heat Stress Disorders 3 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two-way analysis of variance revealed significant increases in blood beta-EP induced by heat and naloxone and a significant interaction between heat and naloxone on blood beta-EP and progesterone (P).
Positive_regulation (induced) of Positive_regulation (increases) of beta-EP in blood associated with narcan
1) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530232 Disease Relevance 0.23 Pain Relevance 0.56
These results suggest that 5-HT is a potent stimulator of both beta-EP and ACTH release and the increase in plasma concentrations of ACTH and beta-EP induced by stress are probably mediated, at least in part, by central serotonergic mechanisms.
Spec (probably) Positive_regulation (mediated) of Positive_regulation (increase) of beta-EP in plasma associated with stress
2) Confidence 0.19 Published 1982 Journal Life Sci. Section Abstract Doc Link 6283286 Disease Relevance 0.27 Pain Relevance 0.39
Beta EP accumulation over 3 and 5 days was markedly increased by inhibitors of steroid biosynthesis (1.5-fold) and reduced by DEX only after treatment for 5 days (by 50%).
Positive_regulation (increased) of Positive_regulation (accumulation) of EP associated with dexamethasone
3) Confidence 0.18 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.18

General Comments

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