INT32543

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.46
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 8 99.98 Very High Very High Very High
antagonist 10 99.64 Very High Very High Very High
opioid receptor 4 98.08 Very High Very High Very High
Opioid 7 86.60 High High
opiate 2 78.52 Quite High
Glutamate 4 75.00 Quite High
acular 2 75.00 Quite High
cINOD 3 74.72 Quite High
cerebral cortex 4 72.24 Quite High
Glutamate receptor 7 70.96 Quite High
Disease Link Frequency Relevance Heat
Brain Injury 75 100.00 Very High Very High Very High
Cancer 5 88.96 High High
Reprotox - General 1 9 85.32 High High
Injury 27 83.52 Quite High
Pressure Volume 2 Under Development 12 83.12 Quite High
INFLAMMATION 3 74.32 Quite High
Stress 1 43.44 Quite Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Negative_regulation (impairment) of Gene_expression (production) of Ep
1) Confidence 0.42 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
Although there was a significant rise in the expression of group I and group III mGluRs (except mGluR6) and a decrease in the expression of group II mGluRs after DBI (P < 0.05), the changes were more severe when DBI was coupled with SBI (P < 0.05).
Negative_regulation (decrease) of Gene_expression (expression) of DBI associated with brain injury
2) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2242800 Disease Relevance 1.67 Pain Relevance 0.14
The delta-antagonist Nti (20-40 nmol) reduced beta END-induced feeding to a lesser degree, and AS ODN probes targeting exon 1, but not 2 or 3, of the delta-opioid receptor clone significantly reduced beta END-induced feeding.
Negative_regulation (reduced) of Gene_expression (probes) of AS ODN associated with antagonist and opioid receptor
3) Confidence 0.24 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303047 Disease Relevance 0 Pain Relevance 0.84
In contrast, testosterone or its metabolites may exert negative autocrine modulation of beta EP production.
Negative_regulation (modulation) of Gene_expression (production) of EP
4) Confidence 0.11 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.19
In contrast, DEX reduced basal and hCG-stimulated beta EP production (by approximately 50%).
Negative_regulation (reduced) of Gene_expression (production) of EP associated with dexamethasone
5) Confidence 0.11 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.28
Calcitriol inhibits the prostaglandin (PG) pathway by three actions: (i) the inhibition of the expression of cyclooxygenase-2 (COX-2), the enzyme that synthesizes PGs, (ii) the induction of the expression of 15-prostaglandin dehydrogenase (15-PGDH), the enzyme that inactivates PGs and (iii) decreasing the expression of EP and FP PG receptors that are essential for PG signaling.
Negative_regulation (decreasing) of Gene_expression (expression) of EP
6) Confidence 0.01 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17229571 Disease Relevance 0.70 Pain Relevance 0.15

General Comments

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