INT32545

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.07
First Reported 1986
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.88
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
median eminence 2
hypothalamus 1
cerebrospinal fluid 1
cerebral spinal fluid 1
pituitary 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 129 99.72 Very High Very High Very High
Inflammation 114 96.64 Very High Very High Very High
depression 150 96.08 Very High Very High Very High
Somatostatin 18 95.52 Very High Very High Very High
Neuropeptide 16 87.84 High High
cytokine 74 85.84 High High
Mechanotransduction 1 84.00 Quite High
Eae 8 83.40 Quite High
Hippocampus 8 80.28 Quite High
Catecholamine 42 75.60 Quite High
Disease Link Frequency Relevance Heat
Cancer 76 100.00 Very High Very High Very High
Necrosis 13 100.00 Very High Very High Very High
Appetite Loss 21 99.36 Very High Very High Very High
Osteoporosis 11 98.84 Very High Very High Very High
Aggression 2 98.58 Very High Very High Very High
INFLAMMATION 129 96.64 Very High Very High Very High
Depression 120 96.08 Very High Very High Very High
Weight Loss 3 95.76 Very High Very High Very High
Stress 159 90.32 High High
Anxiety Disorder 2 79.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corticotropin releasing factor (CRF) given i.c.v. at doses of 0.02-2 nmol, significantly inhibited luteinising hormone (LH) secretion in castrate male rats.
Localization (releasing) of factor
1) Confidence 0.07 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2963219 Disease Relevance 0 Pain Relevance 0.09
hours affected osteoblastic maturation by up-regulating early local factors, such as transforming growth factor (TGF)-?
Localization (transforming) of factor associated with osteoporosis
2) Confidence 0.04 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.47 Pain Relevance 0.04
Furthermore, in a study of perpetrators of domestic violence, DHA levels were inversely related to concentrations of corticotropin-releasing factor in cerebrospinal fluid [143].
Localization (releasing) of factor in cerebrospinal fluid associated with aggression
3) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.50 Pain Relevance 0.28
These findings include elevated basal levels of serum cortisol, increased corticotrophin-releasing factor in cerebral spinal fluid [136–138], and disruption of negative feedback mechanisms [139].
Localization (releasing) of factor in cerebral spinal fluid
4) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.26 Pain Relevance 0.09
Challenge of cultured microglia with lipopolysaccharide (LPS) induced release of tumour necrosis factor alpha (TNF?)
Localization (release) of factor in microglia associated with necrosis and cancer
5) Confidence 0.02 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.30 Pain Relevance 0.11
This peptide was purified and identified by Guillemin's and Schally's group (45) in 1973 as the somatotrophin release-inhibiting factor released from the mediobasal hypothalamus into the portal blood vessels in the median eminence.
Localization (released) of factor in median eminence
6) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0.13
There is also evidence for the existence of a stimulatory paracrine factor released from non-CRH-responsive cells, as medium conditioned by exposure to a pituitary cell population, in which CRH-target cells were destroyed by a CRH-toxin conjugate, was found to increase ACTH secretion in naive pituitary cells (574).
Localization (released) of factor in pituitary
7) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0
This peptide was purified and identified by Guillemin's and Schally's group (45) in 1973 as the somatotrophin release-inhibiting factor released from the mediobasal hypothalamus into the portal blood vessels in the median eminence.
Localization (release) of factor in median eminence
8) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0.13
The mechanisms underlying the anorectic effects of exercise are not known but exercise may reduce food intake by facilitating the release of corticotropin releasing factor (CRF) a potent anorectic peptid [56].
Localization (release) of factor associated with appetite loss
9) Confidence 0.01 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.33 Pain Relevance 0.08
Rivest and Richard [57] and Kawaguchi et al. [58] showed that injecting a corticotropin-releasing factor (CRF) antagonist into the hypothalamus of rats prevented the effects of exercise on food intake and body weight reduction suggesting that CRF plays a major role in the anorexia caused by exercise in rats.
Localization (releasing) of factor in hypothalamus associated with appetite loss, weight loss and antagonist
10) Confidence 0.01 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.49 Pain Relevance 0.08
The mechanisms underlying the anorectic effects of exercise are not known but exercise may reduce food intake by facilitating the release of corticotropin releasing factor (CRF) a potent anorectic peptid [56].
Localization (releasing) of factor associated with appetite loss
11) Confidence 0.01 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox