INT325457

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
cornea 2
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 100.00 Very High Very High Very High
Inflammation 22 97.72 Very High Very High Very High
metalloproteinase 4 96.16 Very High Very High Very High
corticosteroid 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 100.00 Very High Very High Very High
Disorders Of The Lacrimal System 59 99.20 Very High Very High Very High
Disease 24 98.28 Very High Very High Very High
Keratitis 2 89.68 High High
Respiratory Disease 1 81.60 Quite High
Infection 4 74.08 Quite High
Chlamydia Infection 2 40.92 Quite Low
Conjunctivitis 10 26.28 Quite Low
Bacterial Meningitis 1 14.24 Low Low
Hemophilus Infection 1 11.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zymosan, a fungal toll-like receptor-2 ligand that stimulates production of inflammatory mediators in corneal epithelial cells, has been shown to be inhibited by treatment with azithromycin, suggesting another anti-inflammatory mechanism of action for azithromycin in ocular tissue.33 Macrophage and dendritic cell infiltration into the cornea has also been mitigated by topical azithromycin use in a mouse study of keratitis.34


Negative_regulation (inhibited) of toll-like receptor-2 Binding (ligand) of in cornea associated with inflammatory mediators, inflammation and keratitis
1) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915852 Disease Relevance 1.30 Pain Relevance 0.43

General Comments

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