INT325470

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3, MMP9) extracellular space (MMP3, MMP9) extracellular region (MMP3, MMP9)
proteinaceous extracellular matrix (MMP3, MMP9) protein complex (MMP3, MMP9) nucleus (MMP3)
Anatomy Link Frequency
lacrimal gland 1
MMP3 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 3 97.28 Very High Very High Very High
metalloproteinase 11 70.96 Quite High
topical agent 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 17 98.80 Very High Very High Very High
Keratitis 1 94.88 High High
Disorders Of The Lacrimal System 1 92.96 High High
Pathologic Dilatation 4 58.84 Quite High
Dislocations 3 57.72 Quite High
Injury 1 52.32 Quite High
Myopia 4 5.00 Very Low Very Low Very Low
Refractive Errors 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to Sobrin et al, MMP-3 independently activated MMP-9 on the ocular surface, and doxycycline decreased MMP-9 activity in corneal epithelial cultures.8 Zylberberg et al found that both pro-MMP-2 and pro-MMP-9 were secreted by the lacrimal gland, and were likely up-regulated by estrogen.19 Kobayashi reported that leptomycin B reduced MMP-9 expression.4 During corneal wound healing, transforming growth factor-?
MMP-3 Neg (independently) Positive_regulation (activated) of MMP-9 in lacrimal gland associated with disorders of the lacrimal system and wound healing
1) Confidence 0.17 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915870 Disease Relevance 0.90 Pain Relevance 0.20

General Comments

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