INT325490

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ep300) nucleus (Ep300) transferase activity, transferring acyl groups (Ep300)
DNA binding (Ep300) transcription factor binding (Ep300) cytoplasm (Ep300)
Anatomy Link Frequency
astrocyte 1
Ep300 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 17 83.68 Quite High
glial activation 1 79.68 Quite High
cytokine 8 75.28 Quite High
Central nervous system 6 68.20 Quite High
Inflammatory response 3 48.76 Quite Low
Hippocampus 22 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 83.68 Quite High
Disease 33 60.24 Quite High
Increased Venous Pressure Under Development 1 31.28 Quite Low
Apoptosis 20 30.08 Quite Low
Death 4 27.28 Quite Low
Pneumococcal Meningitis 21 26.48 Quite Low
Neurodegenerative Disease 10 25.88 Quite Low
Infection 60 13.36 Low Low
Bacterial Meningitis 28 5.00 Very Low Very Low Very Low
Acute Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There it forms a transcriptional complex with STAT3 and the co-activator p300 on the promoter sequence of the astrocyte-specific genes such as the one for the glial fibrillary acidic protein (GFAP) thereby inducing astrocyte activation [37-40].
Positive_regulation (activator) of p300 in astrocyte
1) Confidence 0.03 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.22 Pain Relevance 0.19

General Comments

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