INT325492

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ep300) nucleus (Ep300) transferase activity, transferring acyl groups (Ep300)
DNA binding (Ep300) transcription factor binding (Ep300) cytoplasm (Ep300)
Anatomy Link Frequency
astrocyte 1
Ep300 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 17 93.04 High High
glial activation 1 89.04 High High
cytokine 8 84.64 Quite High
Central nervous system 6 77.56 Quite High
Inflammatory response 3 58.12 Quite High
Hippocampus 22 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 93.04 High High
Disease 33 51.76 Quite High
Neurodegenerative Disease 10 35.24 Quite Low
Increased Venous Pressure Under Development 1 14.24 Low Low
Apoptosis 20 13.04 Low Low
Infection 60 13.00 Low Low
Death 4 10.24 Low Low
Pneumococcal Meningitis 21 9.44 Low Low
Bacterial Meningitis 28 5.00 Very Low Very Low Very Low
Acute Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of astrocyte activation is also reflected by an up-regulation of BMP-2, STAT3 and p300 which are factors in the BMP signalling pathway.
Regulation (regulation) of p300 in astrocyte
1) Confidence 0.04 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.29 Pain Relevance 0.24

General Comments

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