INT325495

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
microglia 2
Cxcl10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
Inflammation 17 92.60 High High
cytokine 8 67.36 Quite High
Hippocampus 22 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 60 100.00 Very High Very High Very High
Disease 33 100.00 Very High Very High Very High
INFLAMMATION 21 92.60 High High
Apoptosis 20 72.16 Quite High
Bacterial Meningitis 28 68.72 Quite High
Death 4 45.76 Quite Low
Brain Hemorrhage 1 42.68 Quite Low
Pneumococcal Meningitis 21 38.28 Quite Low
Disease Progression 1 38.04 Quite Low
Increased Venous Pressure Under Development 1 19.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.
Regulation (regulation) of Regulation (regulated) of CXCL10 in microglia associated with metalloproteinase, disease and infection
1) Confidence 0.23 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.66 Pain Relevance 0.16

General Comments

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