INT32553

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.64
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pfkm) kinase activity (Pfkm) cytoplasm (Pfkm)
Anatomy Link Frequency
mammary glands 3
muscle 2
spinal cord 1
Pfkm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 2 100.00 Very High Very High Very High
noradrenaline 7 99.90 Very High Very High Very High
Morphine 18 99.84 Very High Very High Very High
Spinal cord 5 99.52 Very High Very High Very High
agonist 3 99.32 Very High Very High Very High
Inflammation 8 99.20 Very High Very High Very High
fluoxetine 3 98.68 Very High Very High Very High
Kinase C 4 97.78 Very High Very High Very High
Hyperalgesia 3 97.76 Very High Very High Very High
dexamethasone 6 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 98.32 Very High Very High Very High
Stress 1 98.06 Very High Very High Very High
Hyperalgesia 4 97.76 Very High Very High Very High
Muscle Weakness 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corticotropin and morphine interaction in the regulation of phosphofructokinase activity in rat mammary gland.
Regulation (regulation) of phosphofructokinase in mammary gland associated with morphine
1) Confidence 0.62 Published 1983 Journal Horm. Res. Section Title Doc Link 6301962 Disease Relevance 0 Pain Relevance 0.66
The roles of corticotropin and morphine in the regulation of phosphofructokinase (PFK) activity in rat mammary glands were investigated by the administration of corticotropin, morphine and dexamethasone.
Regulation (regulation) of PFK in mammary glands associated with dexamethasone and morphine
2) Confidence 0.62 Published 1983 Journal Horm. Res. Section Abstract Doc Link 6301962 Disease Relevance 0 Pain Relevance 0.48
The roles of corticotropin and morphine in the regulation of phosphofructokinase (PFK) activity in rat mammary glands were investigated by the administration of corticotropin, morphine and dexamethasone.
Regulation (regulation) of phosphofructokinase in mammary glands associated with dexamethasone and morphine
3) Confidence 0.54 Published 1983 Journal Horm. Res. Section Abstract Doc Link 6301962 Disease Relevance 0 Pain Relevance 0.48
Exogenous ATP antagonizes the actions of phospholipase A2, local anesthetics, Ca2+ ionophore A23187, and lithium on glucose-1,6-bisphosphate levels and the activities of phosphofructokinase and phosphoglucomutase in rat muscle.
Regulation (actions) of phosphofructokinase in muscle associated with local anesthetic
4) Confidence 0.36 Published 1987 Journal Biochem. Med. Metab. Biol. Section Title Doc Link 2963653 Disease Relevance 0 Pain Relevance 0.19
Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine.
Neg (not) Regulation (regulated) of phosphofructokinase M associated with stress, kinase c and fluoxetine
5) Confidence 0.14 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12435479 Disease Relevance 0.10 Pain Relevance 0.64
BSV mimicked the agonist actions of noradrenaline (NA) by acting directly on postjunctional alpha-adrenoceptors in the anococcygeus muscle.
Regulation (acting) of anococcygeus muscle in muscle associated with noradrenaline and agonist
6) Confidence 0.01 Published 1993 Journal Toxicon Section Abstract Doc Link 8303724 Disease Relevance 0 Pain Relevance 0.65
Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation.
Regulation (modulate) of isozyme in spinal cord associated with inflammation and spinal cord
7) Confidence 0.00 Published 2006 Journal Neuroscience Section Title Doc Link 16360284 Disease Relevance 0.54 Pain Relevance 0.78

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