INT325558

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a) signal transduction (Pde2a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Anatomy Link Frequency
cardiac myocytes 2
Pde2a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 39 96.80 Very High Very High Very High
Targeted Disruption 6 95.36 Very High Very High Very High
Natriuresis 15 50.00 Quite Low
Body Weight 15 5.00 Very Low Very Low Very Low
Hypertrophy 12 5.00 Very Low Very Low Very Low
Hypertension 9 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 9 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 6 5.00 Very Low Very Low Very Low
Anaemia 3 5.00 Very Low Very Low Very Low
Fibrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, our findings are compatible with the notion that PKG I is the downstream target activated by the ANP/GC-A/cGMP-signalling pathway in cardiac myocytes. cGMP/PKG I-mediated modulation of RGS2 and subsequent inhibition of AT1/G?
Negative_regulation (inhibition) of Gene_expression (modulation) of cGMP in cardiac myocytes
1) Confidence 0.11 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Hence, these studies indicate that the NO/sGC/cGMP system acts as a negative modulator of both the cardiac contractile and hypertrophic responses to ?
Negative_regulation (/) of Gene_expression (system) of cGMP
2) Confidence 0.09 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.19 Pain Relevance 0
Hence, these studies indicate that the NO/sGC/cGMP system acts as a negative modulator of both the cardiac contractile and hypertrophic responses to ?
Negative_regulation (acts) of Gene_expression (system) of cGMP
3) Confidence 0.09 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.19 Pain Relevance 0

General Comments

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