INT32557

Context Info Confidence 0.43 First Reported 1988 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 3.44 Pain Relevance 2.10

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1) Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)

Anatomy Link Frequency neck 2 PTGS1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 18 100.00 adenocard 2 99.80 Inflammation 20 99.28 Pain 5 98.72 Potency 6 97.16 Analgesic 3 88.92 Paracetamol 2 81.80 Bile 5 78.08 COX-2 inhibitor 2 75.00 anesthesia 1 63.12

Disease Link Frequency Relevance Heat INFLAMMATION 26 100.00 Fever 3 99.72 Gallstones 4 99.48 Natriuresis 7 98.98 Pain 6 98.72 Increased Venous Pressure Under Development 6 98.24 Breast Cancer 1 97.96 Skin Cancer 5 97.36 Head & Neck Cancer 1 96.44 Body Weight 1 94.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gallstone formation and mitigate biliary pain in gallstone patients.

Negative_regulation (decrease) of Negative_regulation (inhibition) of cyclooxygenase associated with pain, inflammation, cinod and gallstones

1) Confidence 0.43 Published 1993 Journal Clin Investig Section Abstract Doc Link 8312687 Disease Relevance 0.62 Pain Relevance 0.40

Salicylate inhibition of PGHS-1 was prevented by 12-hydroperoxyeicosatetraenoic acid (12-HPETE).

Negative_regulation (prevented) of Negative_regulation (inhibition) of PGHS-1

2) Confidence 0.36 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538810 Disease Relevance 0.09 Pain Relevance 0.25

The PGHS-1 apoenzyme reconstituted with manganese protoporphyrin instead of iron protoporphyrin has very little peroxidase activity. 12-HPETE does not prevent the inhibition of Mn-PGHS-1 by salicylate, indicating that reversal of salicylate inhibition by hydroperoxides depends upon electron transfer between the cyclooxygenase and peroxidase active sites.

Negative_regulation (prevent) of Negative_regulation (inhibition) of Mn-PGHS-1

3) Confidence 0.31 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538810 Disease Relevance 0.05 Pain Relevance 0.19

In contrast, the selective PGHS-2 inhibitor NS-398 exhibited time-independent inhibition of hPGHS-1 but time-dependent inhibition of hPGHS-2 in intact cells.

Negative_regulation (exhibited) of Negative_regulation (inhibition) of hPGHS-1

4) Confidence 0.15 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8831731 Disease Relevance 0.05 Pain Relevance 0.31

BACKGROUND: Indomethacin, an NSAID capable of inhibiting the effect of both cyclooxygenase and lipooxygenase, has been reported to repress the growth of breast cancer, skin cancer and head & neck cancer, etc.

Negative_regulation (inhibiting) of Negative_regulation (inhibiting) of cyclooxygenase in neck associated with breast cancer, cinod, head & neck cancer and skin cancer

5) Confidence 0.14 Published 2002 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 12636206 Disease Relevance 0.62 Pain Relevance 0.10

For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs (NSAIDs), which targets both COX-1 and COX-2 and as such could be responsible for causing gastrointestinal (GI) toxicity.

Negative_regulation (inhibition) of Negative_regulation (inhibition) of cyclooxygenase associated with toxicity, inflammation and cinod

6) Confidence 0.07 Published 2007 Journal Mini Rev Med Chem Section Abstract Doc Link 17584158 Disease Relevance 0.40 Pain Relevance 0.23

Coronary vasodilation produced by human atrial natriuretic peptide was not antagonized by adenosine receptor blockade or by cyclooxygenase inhibition with indomethacin.

Negative_regulation (blockade) of Negative_regulation (inhibition) of cyclooxygenase associated with natriuresis, adenocard and increased venous pressure under development

7) Confidence 0.05 Published 1988 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 2963852 Disease Relevance 1.22 Pain Relevance 0.16

They prevent the formation of important lipid mediators, the prostaglandins (PGs), via inhibition of cyclooxygenase (COX) enzymes.

Negative_regulation (prevent) of Negative_regulation (inhibition) of cyclooxygenase

8) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0.39 Pain Relevance 0.47

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