INT325579

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rgs2) plasma membrane (Rgs2) nucleus (Rgs2)
cell cycle (Rgs2) cytoplasm (Rgs2)
Anatomy Link Frequency
myocytes 1
brachial plexus 1
Rgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 1 88.52 High High
Neurotransmitter 2 68.52 Quite High
Spinal cord 25 64.12 Quite High
medulla 30 63.48 Quite High
cytokine 5 56.20 Quite High
metalloproteinase 1 45.72 Quite Low
Inflammatory mediators 1 41.36 Quite Low
Nerve growth factor 1 39.00 Quite Low
Inflammation 1 20.08 Low Low
cerebral cortex 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 3 58.68 Quite High
Natriuresis 5 50.00 Quite Low
Adhesions 1 46.84 Quite Low
INFLAMMATION 3 40.96 Quite Low
Alzheimer's Dementia 1 29.12 Quite Low
Coronary Heart Disease 13 13.92 Low Low
Pressure Volume 2 Under Development 2 8.40 Low Low
Nervous System Injury 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, when RGS2 was phosphorylated by PKC, GAP activity was reduced, then Gq/11 signals were enhanced [41]; RGS16 phosphorylation could also reduce its GAP activity toward GRi/o and result in increased adrenergic receptor signals [42], then the paralleled increase in RGS4 and PKA induced by brachial plexus avulsion will be expected to unmask their full functional potential, the orchestrated and dynamical RGS4 subcellular distribution and modulation will be the intriguing intracellular signal in response to brachial plexus avulsion.
Phosphorylation (phosphorylated) of RGS2 in brachial plexus
1) Confidence 0.55 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.20
Unfortunately for technical reasons, we could not complement these experiments with analyses of RGS2 expression and/or phosphorylation in wild type when compared with GC-A- or PKG I-deficient myocytes.
Phosphorylation (phosphorylation) of RGS2 in myocytes
2) Confidence 0.51 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.06 Pain Relevance 0

General Comments

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