INT32558

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Context Info
Confidence 0.12
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.77
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA1) endoplasmic reticulum (ADORA1) plasma membrane (ADORA1)
cell-cell signaling (ADORA1) signal transducer activity (ADORA1)
ADORA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 106 100.00 Very High Very High Very High
adenocard 89 100.00 Very High Very High Very High
antagonist 23 100.00 Very High Very High Very High
Pain 11 98.00 Very High Very High Very High
ischemia 16 97.88 Very High Very High Very High
anticonvulsant 2 84.44 Quite High
Serotonin 1 81.72 Quite High
tricyclic antidepressant 1 80.88 Quite High
qutenza 1 75.48 Quite High
topical agent 1 74.76 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 7 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 9 98.62 Very High Very High Very High
Pain 8 98.00 Very High Very High Very High
Cv Unclassified Under Development 17 97.88 Very High Very High Very High
Reperfusion Injury 2 97.52 Very High Very High Very High
Body Weight 4 95.68 Very High Very High Very High
Metabolic Syndrome 43 82.40 Quite High
Obesity 21 81.52 Quite High
Myocardial Infarction 5 79.76 Quite High
Sleep Initiation And Maintenance Disorders 2 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ever since the influential review by Snyder and Sklar [20], caffeine has been perceived as a “magic” nonselective antagonist of ADORA1 and ADORA2A.
Negative_regulation (antagonist) of ADORA1 associated with antagonist
1) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.49 Pain Relevance 0.14
Coronary vasodilation produced by human atrial natriuretic peptide was not antagonized by adenosine receptor blockade or by cyclooxygenase inhibition with indomethacin.
Negative_regulation (blockade) of adenosine receptor associated with natriuresis, adenocard and increased venous pressure under development
2) Confidence 0.04 Published 1988 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 2963852 Disease Relevance 1.23 Pain Relevance 0.16
Recent studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists, adenosine receptor agonists and nitric oxide synthase inhibitors may become useful in the treatment of neurogenic pain.
Negative_regulation (inhibitors) of adenosine receptor associated with pain, adenocard, antagonist and agonist
3) Confidence 0.01 Published 1997 Journal Drugs Aging Section Abstract Doc Link 9359025 Disease Relevance 0.59 Pain Relevance 1.05
In addition, molecular mechanisms involved in adenosine receptor desensitization are discussed.



Negative_regulation (desensitization) of adenosine receptor associated with adenocard
4) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2245999 Disease Relevance 0.05 Pain Relevance 0.30
After all, it has been shown that caffeine blocks the adenosine receptor and that it also abolishes the protective effect on ischemia/reperfusion damage by ischemic preconditioning [28] and by statins [46].
Negative_regulation (blocks) of adenosine receptor associated with adenocard, reperfusion injury and ischemia
5) Confidence 0.01 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2862957 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

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