INT325608

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Rgs2, Pls1) cytosol (Rgs2) plasma membrane (Rgs2)
nucleus (Rgs2) cell cycle (Rgs2) biological_process (Pls1)
Anatomy Link Frequency
myocytes 1
Rgs2 (Mus musculus)
Pls1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 5 50.00 Quite Low
Hypertension 3 31.68 Quite Low
Coronary Heart Disease 13 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, our findings are compatible with the notion that PKG I is the downstream target activated by the ANP/GC-A/cGMP-signalling pathway in cardiac myocytes. cGMP/PKG I-mediated modulation of RGS2 and subsequent inhibition of AT1/Gq-signalling appear to mediate the specific counter regulation of the calcium responses of myocytes to Ang II by ANP.


RGS2 Regulation (modulation) of PKG I in myocytes
1) Confidence 0.00 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0

General Comments

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