INT32568

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Context Info
Confidence 0.65
First Reported 1980
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 10
Disease Relevance 0.42
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GGH) extracellular space (GGH) extracellular region (GGH)
lysosome (GGH)
Anatomy Link Frequency
plasma 2
urine 2
GGH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 13 99.74 Very High Very High Very High
opiate 2 99.60 Very High Very High Very High
antagonist 6 99.12 Very High Very High Very High
Sumatriptan 5 98.18 Very High Very High Very High
dopamine receptor 1 98.04 Very High Very High Very High
narcan 4 96.56 Very High Very High Very High
dexamethasone 5 88.96 High High
Enkephalin 2 88.28 High High
agonist 1 81.92 Quite High
Opioid 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 97.76 Very High Very High Very High
Natriuresis 2 91.24 High High
Syndrome 1 82.08 Quite High
Aging 1 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sumatriptan induced a striking increase in plasma GH levels in the younger group, whereas it slightly increased GH secretion in the older group (f = 9.59, p < 0.02).
Positive_regulation (increased) of Localization (secretion) of GH in plasma associated with sumatriptan
1) Confidence 0.65 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8695049 Disease Relevance 0.08 Pain Relevance 0.47
CONCLUSIONS: These results indicate that clonidine and l-dopa stimulate GH secretion mainly through the release of hypothalamic GHRH, and that arginine- and insulin-induced hypoglycaemia stimulate GH secretion mainly through the inhibition of hypothalamic somatostatin release.
Positive_regulation (stimulate) of Localization (secretion) of GH
2) Confidence 0.40 Published 2002 Journal Eur. J. Endocrinol. Section Body Doc Link 11834428 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH secretion was studied in man using a GHRH antagonist (GHRH-Ant).
Positive_regulation (induced) of Localization (secretion) of GH associated with antagonist and clonidine
3) Confidence 0.40 Published 2002 Journal Eur. J. Endocrinol. Section Abstract Doc Link 11834428 Disease Relevance 0 Pain Relevance 0.22
However, the presence of endogenous hypothalamic GHRH seems to be essential for the maximal stimulation of GH release induced by arginine and insulin.


Positive_regulation (stimulation) of Localization (release) of GH
4) Confidence 0.40 Published 2002 Journal Eur. J. Endocrinol. Section Body Doc Link 11834428 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These results indicate that clonidine and l-dopa stimulate GH secretion mainly through the release of hypothalamic GHRH, and that arginine- and insulin-induced hypoglycaemia stimulate GH secretion mainly through the inhibition of hypothalamic somatostatin release.
Positive_regulation (stimulate) of Localization (secretion) of GH
5) Confidence 0.40 Published 2002 Journal Eur. J. Endocrinol. Section Body Doc Link 11834428 Disease Relevance 0 Pain Relevance 0
The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH release in normal subjects.
Positive_regulation (induced) of Localization (release) of GH associated with clonidine
6) Confidence 0.40 Published 2002 Journal Eur. J. Endocrinol. Section Title Doc Link 11834428 Disease Relevance 0 Pain Relevance 0.24
However, the presence of endogenous hypothalamic GHRH seems to be essential for the maximal stimulation of GH release induced by arginine and insulin.


Positive_regulation (induced) of Localization (release) of GH
7) Confidence 0.27 Published 2002 Journal Eur. J. Endocrinol. Section Body Doc Link 11834428 Disease Relevance 0 Pain Relevance 0
Preliminary results point to a clear potentiation of GH release when the opiate receptor blockade is added to a dopamine receptor stimulation.
Spec (clear) Positive_regulation (potentiation) of Localization (release) of GH associated with dopamine receptor and opiate
8) Confidence 0.22 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 6257257 Disease Relevance 0 Pain Relevance 0.23
An increase in endogenous GH secretion or a direct hepatic effect have been suggested as possible mechanisms.
Positive_regulation (increase) of Localization (secretion) of GH
9) Confidence 0.15 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11817711 Disease Relevance 0.08 Pain Relevance 0.19
Both analogues, when injected i.v. at a dose of 100 micrograms, stimulated release of prolactin and GH and inhibited serum cortisol; there was no significant change in blood pressure, pulse rate or urine output.
Positive_regulation (stimulated) of Localization (release) of GH in urine associated with cv unclassified under development
10) Confidence 0.13 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2965206 Disease Relevance 0.26 Pain Relevance 0.35

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