INT325766

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Omd) lyase activity (Ddc) cell adhesion (Omd)
proteinaceous extracellular matrix (Omd) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
Anatomy Link Frequency
plasma 1
Ddc (Rattus norvegicus)
Omd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 3 72.12 Quite High
Bioavailability 6 36.52 Quite Low
Potency 3 30.40 Quite Low
Dopamine 14 27.80 Quite Low
Glutamate 19 5.00 Very Low Very Low Very Low
Catecholamine 5 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyskinesias 3 96.16 Very High Very High Very High
Disease 24 95.24 Very High Very High Very High
Stress 12 62.16 Quite High
Toxicity 1 30.72 Quite Low
Alzheimer's Dementia 1 11.84 Low Low
Death 9 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exact cause of these adverse effects has not been established at present. 3-OMD, a major metabolite of L-DOPA formed in peripheral and brain tissues, was detected at high levels in the plasma as well as cerebral spinal fluid of PD patients treated with L-DOPA/carbidopa [43], [44], and the plasma levels of 3-OMD in patients with dyskinesia were significantly higher than those from patients without dyskinesia [45].
L-DOPA Binding (metabolite) of 3-OMD in plasma associated with disease and dyskinesias
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0.59 Pain Relevance 0.04

General Comments

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