INT325770

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPOR, PIK3R2) cytosol (PIK3R2) extracellular region (EPOR)
intracellular (PIK3R2) plasma membrane (EPOR) embryo development (EPOR)
EPOR (Homo sapiens)
PIK3R2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 5 92.24 High High
Hyperplasia 1 88.96 High High
Erythrocytosis 11 50.00 Quite Low
Myelodysplastic Syndromes 15 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Infarction 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Fatty Liver 1 5.00 Very Low Very Low Very Low
Cirrhosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the mechanism is in accord with a recent investigation demonstrating that phosphorylated Y429, Y431, and Y479 in the EPOR cytoplasmic domain bind the p85 subunit of PI3 kinase on EPO stimulation and individually are involved in mediating EPO-dependent EPOR internalization [36].
EPOR Binding (bind) of p85 subunit
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.18 Pain Relevance 0

General Comments

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