INT325791

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.34
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPOR) extracellular region (EPOR) plasma membrane (EPOR)
embryo development (EPOR)
Anatomy Link Frequency
bone marrow 1
spleen 1
EPOR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 32 94.96 High High
ischemia 8 79.36 Quite High
headache 24 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 40 92.24 High High
Hyperplasia 8 88.96 High High
Coronary Artery Disease 8 80.24 Quite High
Infarction 8 78.64 Quite High
Hypertension 8 77.20 Quite High
Myelodysplastic Syndromes 120 67.48 Quite High
Targeted Disruption 8 58.72 Quite High
Erythrocytosis 88 53.76 Quite High
Myeloproliferative Disorder 8 45.36 Quite Low
Disease 8 22.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EPOR engagement stimulates JAK2 phosphorylation at Y1007/1008 residues [3].
EPOR Binding (engagement) of
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.06
In the mouse spleen and bone marrow, EPOR engagement regulates erythropoiesis [6], while the EPO importance in brain development and, possibly, in endothelial precursor mobilization has been suggested [7], [8].
EPOR Binding (engagement) of in spleen
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.35 Pain Relevance 0.04
In order to highlight the biochemical consequences of the truncated receptor accumulation, the possibility that the two EPOR isoforms might interact to form a heterodimer was investigated.
EPOR Spec (might) Binding (interact) of
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.16 Pain Relevance 0
In addition, the mechanism is in accord with a recent investigation demonstrating that phosphorylated Y429, Y431, and Y479 in the EPOR cytoplasmic domain bind the p85 subunit of PI3 kinase on EPO stimulation and individually are involved in mediating EPO-dependent EPOR internalization [36].
EPOR Binding (internalization) of
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.17 Pain Relevance 0
Although these observations are consistent with participation of EPOR in vasculogenesis, the precise contribution of EPOR function in nonhematopoietic tissue remains to be defined, and is the object of intense debate.
EPOR Binding (participation) of
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.14 Pain Relevance 0.04
In addition, the mechanism is in accord with a recent investigation demonstrating that phosphorylated Y429, Y431, and Y479 in the EPOR cytoplasmic domain bind the p85 subunit of PI3 kinase on EPO stimulation and individually are involved in mediating EPO-dependent EPOR internalization [36].
EPOR Binding (bind) of
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.18 Pain Relevance 0
As with other members, the extracellular ligand binding region of EPOR contains four conserved cysteine residues and a WSXWS motif.
EPOR Binding (binding) of
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.09
In the mouse spleen and bone marrow, EPOR engagement regulates erythropoiesis [6], while the EPO importance in brain development and, possibly, in endothelial precursor mobilization has been suggested [7], [8].
EPOR Binding (engagement) of in bone marrow
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.35 Pain Relevance 0.04

General Comments

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