INT325802

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.68
Pain Relevance 0.04

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signal transduction (EPOR) extracellular region (EPOR) plasma membrane (EPOR)
embryo development (EPOR)
Anatomy Link Frequency
body 1
EPOR (Homo sapiens)
EPOR - G1251T (2)
Pain Link Frequency Relevance Heat
cytokine 28 71.80 Quite High
headache 21 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 105 89.60 High High
Myeloproliferative Disorder 7 86.44 High High
Erythrocytosis 77 50.00 Quite Low
Hypersensitivity 35 25.92 Quite Low
Headache 21 5.00 Very Low Very Low Very Low
Cancer 14 5.00 Very Low Very Low Very Low
Infarction 7 5.00 Very Low Very Low Very Low
Hyperplasia 7 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low
Fatty Liver 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both methods demonstrated that mutant EPOR G1251T and wild type EPOR alleles were expressed at similar levels and that the total EPOR transcript of the EPOR G1251T erythroid precursors corresponds to the EPOR mRNA of erythroid precursors of an healthy subject (Figure 3D).
Transcription (transcript) of EPOR (G1251T)
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.07 Pain Relevance 0
Both methods demonstrated that mutant EPOR G1251T and wild type EPOR alleles were expressed at similar levels and that the total EPOR transcript of the EPOR G1251T erythroid precursors corresponds to the EPOR mRNA of erythroid precursors of an healthy subject (Figure 3D).
Transcription (expressed) of EPOR
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.08 Pain Relevance 0
Both methods demonstrated that mutant EPOR G1251T and wild type EPOR alleles were expressed at similar levels and that the total EPOR transcript of the EPOR G1251T erythroid precursors corresponds to the EPOR mRNA of erythroid precursors of an healthy subject (Figure 3D).
Transcription (expressed) of EPOR (G1251T)
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.13 Pain Relevance 0
Both methods demonstrated that mutant EPOR G1251T and wild type EPOR alleles were expressed at similar levels and that the total EPOR transcript of the EPOR G1251T erythroid precursors corresponds to the EPOR mRNA of erythroid precursors of an healthy subject (Figure 3D).
Transcription (transcript) of EPOR
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.07 Pain Relevance 0
Mutational analysis and evaluation of EPOR mRNA isoforms
Transcription (analysis) of EPOR
5) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.17 Pain Relevance 0.04
It is to underline that CEPs EPOR mRNA is easily detectable and that it corresponds to about 10% of EPOR mRNA of erythroid precursors, the cells that probably express the major amount of this transcript in the human body (Figure 3E).
Transcription (detectable) of EPOR in body
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0
The growth characteristics of the EPOR G1251T CD34+ cells and the increased levels of peripheral CEPs prompted us to investigate EPOR mRNA and protein levels during CD34+ erythroid differentiation in vitro.
Spec (investigate) Transcription (levels) of EPOR
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.15 Pain Relevance 0

General Comments

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