INT325809

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
cell-cell signaling (CXCL13)
Anatomy Link Frequency
B cell 2
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 10 97.20 Very High Very High Very High
Multiple sclerosis 34 96.24 Very High Very High Very High
Inflammation 9 95.32 Very High Very High Very High
cytokine 2 84.60 Quite High
chemokine 4 71.20 Quite High
Nerve growth factor 1 56.32 Quite High
imagery 20 45.36 Quite Low
Spinal cord 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 76 99.84 Very High Very High Very High
Demyelinating Disease 34 96.24 Very High Very High Very High
Disease 9 95.64 Very High Very High Very High
INFLAMMATION 9 95.32 Very High Very High Very High
Adhesions 1 70.32 Quite High
Lumbar Puncture Related Headaches 2 12.76 Low Low
Measles 3 5.00 Very Low Very Low Very Low
Togavirus Infection 3 5.00 Very Low Very Low Very Low
Herpes Zoster 3 5.00 Very Low Very Low Very Low
Viral Meningitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observation of elevated CSF CXCL13 in CIS patients with presence of OCB and positive MRZR (Figure 2) demonstrates the association of CXCL13 with the polyspecific intrathecal B cell response in MS, which was suggested to derive from long-lived plasma cells in an enhanced B cell-promoting environment [7].
Positive_regulation (observation) of Positive_regulation (elevated) of CXCL13 in B cell associated with multiple sclerosis, syndrome and intrathecal
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.19 Pain Relevance 0.64

General Comments

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