INT32581

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 11.17
Pain Relevance 9.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4B) extracellular region (C4B)
Anatomy Link Frequency
hypothalamus 2
eye 1
neurons 1
autonomic 1
C4B (Homo sapiens)
Pain Link Frequency Relevance Heat
Cluster headache 836 100.00 Very High Very High Very High
positron emission tomography 16 99.54 Very High Very High Very High
Substantia nigra 18 99.36 Very High Very High Very High
alcohol 16 97.84 Very High Very High Very High
Pain 148 96.20 Very High Very High Very High
Migraine 80 93.44 High High
headache 277 91.52 High High
Inflammation 26 89.60 High High
Dopamine 9 86.16 High High
opiate 4 58.08 Quite High
Disease Link Frequency Relevance Heat
Cluster Headache 844 100.00 Very High Very High Very High
Sickle Cell Anemia 9 95.78 Very High Very High Very High
Headache 301 93.44 High High
Injury 9 91.40 High High
Plasma Cell Granuloma 4 89.60 High High
Disease 167 86.88 High High
Eyelid Disease 4 85.04 High High
Miosis 20 84.60 Quite High
Ocular Toxicity (including Many Sub-types) 20 84.28 Quite High
Pain 129 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean C4b-binding protein levels were normal in subjects with sickle cell disease, both during painful crisis and in the steady state, and no correlation was observed between the levels of C4b-binding protein and free protein S, suggesting that the low free protein S level was not caused by increased levels of C4b-binding protein.
Positive_regulation (increased) of C4b associated with sickle cell anemia and pain
1) Confidence 0.45 Published 1988 Journal J. Lab. Clin. Med. Section Abstract Doc Link 2966224 Disease Relevance 0.64 Pain Relevance 0.17
Our sample size is large enough to yield statistical significance for a CH prevalence of 5.5 % in our group (or 6.2 %, depending on the assumed population-wide CH prevalence), but might be too small to detect a slight increase of CH among patients after removal of an eye.


Positive_regulation (increase) of CH in eye associated with cluster headache
2) Confidence 0.32 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1079865 Disease Relevance 1.15 Pain Relevance 1.07
This led us to the hypothesis that lesions of the autonomic network might induce secondary CH in patients after enucleation [19].
Spec (might) Positive_regulation (induce) of CH in autonomic associated with cluster headache
3) Confidence 0.32 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1079865 Disease Relevance 1.09 Pain Relevance 0.98
The power analysis revealed that a CH prevalence of 5.5 or more in our group of 112 patients would have resulted in a significant increase of CH prevalence (based on a population-wide CH prevalence of 56/100,000 [25]).
Positive_regulation (increase) of CH associated with cluster headache
4) Confidence 0.21 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1079865 Disease Relevance 1.17 Pain Relevance 0.91
We cannot exclude the possibility that enucleation is associated with a small increase in CH prevalence.


Positive_regulation (increase) of CH associated with cluster headache
5) Confidence 0.21 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1079865 Disease Relevance 0.94 Pain Relevance 0.87
Positron emission tomography (PET) studies have show an activation of the posterior hypothalamus during CH attacks [27], reinforcing the idea that the hypothalamus may be the CH generator.
Positive_regulation (activation) of CH in hypothalamus associated with cluster headache and positron emission tomography
6) Confidence 0.14 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2517059 Disease Relevance 1.42 Pain Relevance 1.33
Alcohol is the only dietary trigger of CH, strong odors (mainly solvents and cigarette smoke) and napping may also trigger CH attacks.
Spec (may) Positive_regulation (trigger) of CH associated with cluster headache and alcohol
7) Confidence 0.13 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2517059 Disease Relevance 1.37 Pain Relevance 0.95
Strong odors (mainly solvents and cigarette smoke) and napping may trigger CH attacks.
Spec (may) Positive_regulation (trigger) of CH associated with cluster headache
8) Confidence 0.13 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2517059 Disease Relevance 0.97 Pain Relevance 0.99
Voxel-based morphometry studies demonstrated an increase in the gray matter volume of the posterior hypothalamus in CH patients compared to controls [28].
Positive_regulation (increase) of CH in hypothalamus associated with cluster headache
9) Confidence 0.13 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2517059 Disease Relevance 1.21 Pain Relevance 1.40
Depending on the brick level, we observed a 21- to 59-fold increase in the CH site mutation rate at brick SNPs as compared with all bricks (table 2).
Positive_regulation (increase) of CH
10) Confidence 0.09 Published 2010 Journal Molecular Biology and Evolution Section Body Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0
The increase in iC3b immunoreactivity on melanized neurons in YN substantia nigra specimens in comparison with AN specimens was an unexpected finding.
Positive_regulation (increase) of iC3b in neurons associated with substantia nigra
11) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1626447 Disease Relevance 0.59 Pain Relevance 0.36
Both types of C3 convertases will cleave C3, forming C3b.
Positive_regulation (forming) of C3b
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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