INT325816

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.13
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Dnm1) GTPase activity (Dnm1) protein complex (Dnm1)
cytoplasm (Dnm1)
Anatomy Link Frequency
neurons 3
neuronal 1
Dnm1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 42 98.26 Very High Very High Very High
Pyramidal cell 24 91.76 High High
cerebral cortex 6 90.44 High High
Somatosensory cortex 12 89.76 High High
Neurotransmitter 12 51.80 Quite High
Neuronal excitability 6 27.44 Quite Low
depression 24 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 24 99.44 Very High Very High Very High
Convulsion 204 95.48 Very High Very High Very High
Congenital Anomalies 24 94.64 High High
Shock 6 88.72 High High
Congenital Structural Myopathies 6 84.00 Quite High
Epilepsy 90 50.00 Quite Low
Paralysis 6 11.12 Low Low
Ataxia 42 5.00 Very Low Very Low Very Low
Sprains And Strains 36 5.00 Very Low Very Low Very Low
Depression 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We focused on GABAergic transmission because recent studies using neuronal cell culture demonstrated that the loss of Dnm1 preferentially affects inhibition [9].
Negative_regulation (loss) of Dnm1 in neuronal associated with gabaergic
1) Confidence 0.59 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.09 Pain Relevance 0.30
In cortical neuron cultures established from Dnm1 null mice, inhibitory neurons are shown to be the most sensitive to loss of Dnm1, acquiring a large build up of endocytic intermediates during spontaneous network activity [10].
Negative_regulation (loss) of Dnm1 in neurons
2) Confidence 0.59 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.32 Pain Relevance 0
Silencing transmission relieves the endocytic defect - suggesting that the high intrinsic level of tonic activity of these cortical inhibitory neurons makes them more vulnerable to the lack of Dnm1 [10].
Negative_regulation (lack) of Dnm1 in neurons
3) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.27 Pain Relevance 0
These results confirm that DNM1aFtfl is defective in self-assembly.
Negative_regulation (defective) of DNM1aFtfl
4) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0 Pain Relevance 0
DNM1 protein assembly defect in fitful mice
Negative_regulation (defect) of DNM1 protein
5) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.10 Pain Relevance 0
In Dnm1 null mice, inhibitory neurons are more sensitive to the loss of Dnm1 and experience endocytic defects [9], [10], but neither the homozygous nor the heterozygous Dnm1 null mice have seizures [9].
Negative_regulation (loss) of Dnm1 in neurons associated with convulsion
6) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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