INT325850

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps3) cytoplasm (Hps3)
Anatomy Link Frequency
blood 1
Hps3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 90 99.52 Very High Very High Very High
Bacteremia 50 92.92 High High
Abscess 315 91.24 High High
Sprains And Strains 125 79.52 Quite High
Disease 65 75.60 Quite High
Immunization 45 41.76 Quite Low
Sepsis 30 36.00 Quite Low
Yersinia Infection 5 26.88 Quite Low
Staphylococcus Infection 75 20.76 Low Low
Rhinitis 25 19.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the coagulase-fibrinogen interaction, coagulase was injected at 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM, 50 nM, 100 nM, and 300 nM for 60 seconds of association followed by 60 seconds of dissociation and the chip was regenerated as described above.
coa Binding (interaction) of
1) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
vWbp antibodies interfere with the association between coagulases and clotting factors.
coa Binding (association) of associated with coagulation disorder
2) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.19 Pain Relevance 0
The KD for the coagulase·prothrombin interaction is lower than the reported affinity for the D1D2 domain alone [36]; we currently do not appreciate the basis for this difference.
coa Binding (interaction) of
3) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.25 Pain Relevance 0
Using this assay, we observed that staphylococcal variants lacking coagulase activity displayed delays in clotting time, ?
coa Binding (activity) of associated with coagulation disorder
4) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.63 Pain Relevance 0
Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin, thereby converting fibrinogen to fibrin and promoting clotting of plasma or blood.
coa Binding (binds) of in blood associated with coagulation disorder
5) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.92 Pain Relevance 0

General Comments

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