INT325850

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 1.98 Pain Relevance 0

pigmentation (Hps3) cytoplasm (Hps3)

Anatomy Link Frequency blood 1 Hps3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 10 5.00 Pain 5 5.00 Arthritis 5 5.00

Disease Link Frequency Relevance Heat Coagulation Disorder 90 99.52 Bacteremia 50 92.92 Abscess 315 91.24 Sprains And Strains 125 79.52 Disease 65 75.60 Immunization 45 41.76 Sepsis 30 36.00 Yersinia Infection 5 26.88 Staphylococcus Infection 75 20.76 Rhinitis 25 19.08

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For the coagulase-fibrinogen interaction, coagulase was injected at 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM, 50 nM, 100 nM, and 300 nM for 60 seconds of association followed by 60 seconds of dissociation and the chip was regenerated as described above.

coa Binding (interaction) of

1) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0

vWbp antibodies interfere with the association between coagulases and clotting factors.

coa Binding (association) of associated with coagulation disorder

2) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.19 Pain Relevance 0

The KD for the coagulase·prothrombin interaction is lower than the reported affinity for the D1D2 domain alone [36]; we currently do not appreciate the basis for this difference.

coa Binding (interaction) of

3) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.25 Pain Relevance 0

Using this assay, we observed that staphylococcal variants lacking coagulase activity displayed delays in clotting time, ?

coa Binding (activity) of associated with coagulation disorder

4) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.63 Pain Relevance 0

Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin, thereby converting fibrinogen to fibrin and promoting clotting of plasma or blood.

coa Binding (binds) of in blood associated with coagulation disorder

5) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.92 Pain Relevance 0

General Comments

This test has worked.