INT325857

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 9.66
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps3) cytoplasm (Hps3)
Anatomy Link Frequency
blood 1
skin 1
Hps3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 50.56 Quite High
Pain 10 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 180 100.00 Very High Very High Very High
Sprains And Strains 250 99.98 Very High Very High Very High
Staphylococcus Infection 150 99.46 Very High Very High Very High
Abscess 630 98.76 Very High Very High Very High
Rhinitis 50 98.48 Very High Very High Very High
Cv Unclassified Under Development 10 98.08 Very High Very High Very High
Bacteremia 100 97.76 Very High Very High Very High
Mrsa Infection 60 96.28 Very High Very High Very High
Disease 130 96.24 Very High Very High Very High
Immunization 90 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coagulase (Coa) has been studied for more than 100 years [12], [13] and is secreted by virtually all S. aureus isolates [14], [15].
Localization (secreted) of Coa
1) Confidence 0.78 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.61 Pain Relevance 0
Based on these observations, we propose that the clotting of fibrin by secreted coagulases is a critical event in the establishment of staphylococcal communities surrounded by eosinophilic pseudocapsules and subsequent abscess development.
Localization (secreted) of coa associated with rhinitis, coagulation disorder and abscess
2) Confidence 0.78 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.13 Pain Relevance 0
Expression of Coa and vWbp in abscess lesions as well as their striking distribution in the eosinophilic pseudocapsule surrounding staphylococcal abscess communities suggests that secreted coagulases contribute to the establishment of these lesions.
Localization (secreted) of coa associated with staphylococcus infection, rhinitis and abscess
3) Confidence 0.78 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.12 Pain Relevance 0
Another secreted coagulase, designated von-Willebrand factor binding protein (vWbp), catalyzes a similar reaction.
Localization (secreted) of coa
4) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.93 Pain Relevance 0
Of note, S. aureus Newman secretes large amounts of coagulase due to a point mutation in the two-component regulatory gene saeS [40].
Localization (secretes) of coa
5) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.20 Pain Relevance 0
More recent investigations used molecular genetic tools to generate isogenic coa mutations, however the resulting variants of S. aureus 8325-4, a laboratory strain that secretes relatively little coagulase, did not display virulence phenotypes in endocarditis, skin abscess and mastitis models in mice [16], [39].
Localization (secretes) of coa in skin associated with staphylococcus infection, cv unclassified under development, abscess and sprains and strains
6) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.29 Pain Relevance 0
S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp).
Localization (secretes) of coa associated with coagulation disorder
7) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.59 Pain Relevance 0
Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin, thereby converting fibrinogen to fibrin and promoting clotting of plasma or blood.
Localization (secrete) of coa in blood associated with coagulation disorder
8) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.91 Pain Relevance 0
The vast majority of clinically relevant S. aureus strains secrete coagulase and vWbp [14], [23].
Localization (secrete) of coa associated with sprains and strains
9) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.29 Pain Relevance 0.03
One plausible explanation for the observations of Rothfork and colleagues is that secreted coagulases contribute to the pathogenesis of staphylococcal infections in the presence fibrinogen but not in its absence.
Localization (secreted) of coa associated with staphylococcus infection
10) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.58 Pain Relevance 0

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