INT325857

Context Info Confidence 0.78 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 10 Disease Relevance 9.66 Pain Relevance 0.03

pigmentation (Hps3) cytoplasm (Hps3)

Anatomy Link Frequency blood 1 skin 1 Hps3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 20 50.56 Pain 10 5.00 Arthritis 10 5.00

Disease Link Frequency Relevance Heat Coagulation Disorder 180 100.00 Sprains And Strains 250 99.98 Staphylococcus Infection 150 99.46 Abscess 630 98.76 Rhinitis 50 98.48 Cv Unclassified Under Development 10 98.08 Bacteremia 100 97.76 Mrsa Infection 60 96.28 Disease 130 96.24 Immunization 90 90.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Coagulase (Coa) has been studied for more than 100 years [12], [13] and is secreted by virtually all S. aureus isolates [14], [15].

Localization (secreted) of Coa

1) Confidence 0.78 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.61 Pain Relevance 0

Based on these observations, we propose that the clotting of fibrin by secreted coagulases is a critical event in the establishment of staphylococcal communities surrounded by eosinophilic pseudocapsules and subsequent abscess development.

Localization (secreted) of coa associated with rhinitis, coagulation disorder and abscess

2) Confidence 0.78 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.13 Pain Relevance 0

Expression of Coa and vWbp in abscess lesions as well as their striking distribution in the eosinophilic pseudocapsule surrounding staphylococcal abscess communities suggests that secreted coagulases contribute to the establishment of these lesions.

Localization (secreted) of coa associated with staphylococcus infection, rhinitis and abscess

3) Confidence 0.78 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.12 Pain Relevance 0

Another secreted coagulase, designated von-Willebrand factor binding protein (vWbp), catalyzes a similar reaction.

Localization (secreted) of coa

4) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.93 Pain Relevance 0

Of note, S. aureus Newman secretes large amounts of coagulase due to a point mutation in the two-component regulatory gene saeS [40].

Localization (secretes) of coa

5) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.20 Pain Relevance 0

More recent investigations used molecular genetic tools to generate isogenic coa mutations, however the resulting variants of S. aureus 8325-4, a laboratory strain that secretes relatively little coagulase, did not display virulence phenotypes in endocarditis, skin abscess and mastitis models in mice [16], [39].

Localization (secretes) of coa in skin associated with staphylococcus infection, cv unclassified under development, abscess and sprains and strains

6) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.29 Pain Relevance 0

S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp).

Localization (secretes) of coa associated with coagulation disorder

7) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.59 Pain Relevance 0

Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin, thereby converting fibrinogen to fibrin and promoting clotting of plasma or blood.

Localization (secrete) of coa in blood associated with coagulation disorder

8) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.91 Pain Relevance 0

The vast majority of clinically relevant S. aureus strains secrete coagulase and vWbp [14], [23].

Localization (secrete) of coa associated with sprains and strains

9) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 1.29 Pain Relevance 0.03

One plausible explanation for the observations of Rothfork and colleagues is that secreted coagulases contribute to the pathogenesis of staphylococcal infections in the presence fibrinogen but not in its absence.

Localization (secreted) of coa associated with staphylococcus infection

10) Confidence 0.68 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.58 Pain Relevance 0

General Comments

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