INT325901

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
cleavage 1
Dio1 (Mus musculus)
F2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 30 92.24 High High
Sprains And Strains 50 84.92 Quite High
Abscess 126 74.72 Quite High
Sepsis 12 61.84 Quite High
Staphylococcus Infection 30 55.36 Quite High
Disease 26 50.00 Quite Low
Rupture 4 8.32 Low Low
Coagulation Disorder 36 5.00 Very Low Very Low Very Low
Bacteremia 20 5.00 Very Low Very Low Very Low
Immunization 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The crystal structure of the active complex revealed binding of the D1 and D2 domains to prothrombin and insertion of the Ile1-Val2 N-terminus of Coa into the Ile16 pocket of prothrombin, inducing a functional active site in the zymogen through conformational change [20].
D1 Binding (binding) of prothrombin
1) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.37 Pain Relevance 0
The D1 and D2 domains of vWbp display 30% amino acid identity with the corresponding domain of coagulase and also associate with prothrombin, activating the zymogen and promoting cleavage of fibrinogen to fibrin [24].
D1 Binding (associate) of prothrombin in cleavage
2) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.26 Pain Relevance 0

General Comments

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