INT325904

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
cellular_component (Wbp5) biological_process (Wbp5)
Anatomy Link Frequency
cleavage 1
F2 (Mus musculus)
Wbp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Abscess 252 96.84 Very High Very High Very High
Sprains And Strains 100 96.24 Very High Very High Very High
Sepsis 24 92.72 High High
Disease 52 89.56 High High
Coagulation Disorder 72 80.80 Quite High
Bacteremia 40 68.36 Quite High
Staphylococcus Infection 60 55.36 Quite High
Infection 60 36.48 Quite Low
Immunization 36 31.52 Quite Low
Mrsa Infection 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess vWbp-prothrombin and vWbp-fibrinogen interactions, vWbp was injected at 1 nM, 10 nM, 50 nM, 100 nM, 500 nM, and 1 µM for 60 seconds followed by 60 seconds of dissociation and regeneration.
prothrombin Binding (interactions) of vWbp
1) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
The D1 and D2 domains of vWbp display 30% amino acid identity with the corresponding domain of coagulase and also associate with prothrombin, activating the zymogen and promoting cleavage of fibrinogen to fibrin [24].
prothrombin Binding (associate) of vWbp in cleavage
2) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.26 Pain Relevance 0
Antibodies directed against Coa or vWbp prevent coagulase binding to prothrombin or fibrinogen and confer protection against challenge with S. aureus Newman or the methicillin-resistant S. aureus isolate USA300 LAC in mouse models of abscess formation or lethal sepsis.
prothrombin Binding (binding) of vWbp associated with abscess and sepsis
3) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.96 Pain Relevance 0
To assess vWbp-prothrombin and vWbp-fibrinogen interactions, vWbp was injected at 1 nM, 10 nM, 50 nM, 100 nM, 500 nM, and 1 µM for 60 seconds followed by 60 seconds of dissociation and regeneration.
prothrombin Binding (interactions) of vWbp
4) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0

General Comments

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