INT325906

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps3) signal transduction (Fgg) extracellular space (Fgg)
extracellular region (Fgg) protein binding, bridging (Fgg) cytoplasm (Hps3)
Hps3 (Mus musculus)
Fgg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Abscess 252 96.32 Very High Very High Very High
Sprains And Strains 100 95.72 Very High Very High Very High
Sepsis 24 93.28 High High
Disease 52 89.04 High High
Coagulation Disorder 72 80.28 Quite High
Bacteremia 40 67.84 Quite High
Immunization 36 59.00 Quite High
Staphylococcus Infection 60 5.00 Very Low Very Low Very Low
Infection 60 5.00 Very Low Very Low Very Low
Mrsa Infection 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To measure the interaction of coagulase with prothrombin and fibrinogen, Coa was diluted into HBS-P buffer (20 mM HEPES [pH 7.4], 150 mM NaCl, 0.005% [vol/vol] surfactant P20) at a range of concentrations.
coa Binding (interaction) of fibrinogen
1) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.06 Pain Relevance 0
For the coagulase-fibrinogen interaction, coagulase was injected at 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM, 50 nM, 100 nM, and 300 nM for 60 seconds of association followed by 60 seconds of dissociation and the chip was regenerated as described above.
coa Binding (interaction) of fibrinogen
2) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
For the coagulase-fibrinogen interaction, coagulase was injected at 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM, 50 nM, 100 nM, and 300 nM for 60 seconds of association followed by 60 seconds of dissociation and the chip was regenerated as described above.
coa Binding (interaction) of fibrinogen
3) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
Antibodies directed against Coa or vWbp prevent coagulase binding to prothrombin or fibrinogen and confer protection against challenge with S. aureus Newman or the methicillin-resistant S. aureus isolate USA300 LAC in mouse models of abscess formation or lethal sepsis.
coa Binding (binding) of fibrinogen associated with abscess and sepsis
4) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.91 Pain Relevance 0

General Comments

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