INT325927

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Context Info
Confidence 0.82
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.74
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
plasma 1
lymph node 1
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 66 92.12 High High
metalloproteinase 6 14.08 Low Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 246 98.60 Very High Very High Very High
Cancer 162 98.40 Very High Very High Very High
Pancreatic Cancer 132 96.78 Very High Very High Very High
Adhesions 18 92.60 High High
Pancreatitis 66 92.12 High High
Adenocarcinoma 162 91.24 High High
Stress 6 88.40 High High
Apoptosis 6 79.00 Quite High
Melanoma 12 75.52 Quite High
Malignant Neoplastic Disease 30 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been recently reported that phosphorylation of ezrin is required for metastatic behavior of tumor cells [31].
Phosphorylation (phosphorylation) of ezrin associated with cancer
1) Confidence 0.82 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.28 Pain Relevance 0
Therefore, phosphorylation of ezrin may not affect the motility and invasion ability of MiaPaCa-2 cells in vitro.
Phosphorylation (phosphorylation) of ezrin
2) Confidence 0.82 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.37 Pain Relevance 0
Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.
Phosphorylation (phosphorylation) of ezrin in lymph node associated with pancreatic cancer and metastasis
3) Confidence 0.82 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0
Rabbit polyclonal anti-phosphorylated Ezrin (Tyr353), mouse monoclonal anti-AKT, anti-phospho-AKT (Ser473), anti-p44/42 MAPK (Erk1/2) and anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA).
Phosphorylation (phosphorylated) of Ezrin
4) Confidence 0.82 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.93 Pain Relevance 0.09
Phosphorylation of ezrin induces its translocation from the cytoplasm to the plasma membranes of microvillus and confers the ability of binding to plasma membrane and actin filaments [9-12].
Phosphorylation (Phosphorylation) of ezrin in plasma
5) Confidence 0.82 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.34 Pain Relevance 0
Upon threonine and tyrosine phosphorylation, ezrin assumes an active, "open" conformation and, in turn, moves to the cell membrane and directly or indirectly tethers F-actin to the cell membrane.
Phosphorylation (phosphorylation) of ezrin
6) Confidence 0.63 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.44 Pain Relevance 0

General Comments

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