INT325930

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 75
Total Number 76
Disease Relevance 59.77
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
ducts 6
lymph node 5
pancreatic ducts 4
E cells 2
B cells 2
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 803 99.74 Very High Very High Very High
Spinal cord 73 92.88 High High
metalloproteinase 73 88.00 High High
Hippocampus 22 61.44 Quite High
agonist 16 50.96 Quite High
cerebral cortex 12 5.00 Very Low Very Low Very Low
Thalamus 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
interneuron 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 2993 100.00 Very High Very High Very High
Cancer 1973 100.00 Very High Very High Very High
Adenocarcinoma 1971 99.92 Very High Very High Very High
Pancreatic Ductal Carcinoma 219 99.84 Very High Very High Very High
Pancreatitis 803 99.74 Very High Very High Very High
Pancreatic Cancer 1606 99.70 Very High Very High Very High
Osteogenic Sarcomas 146 99.56 Very High Very High Very High
Rhabdomyosarcoma 146 99.16 Very High Very High Very High
Malignant Neoplastic Disease 365 98.92 Very High Very High Very High
Gastrointestinal Stromal Tumor 73 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis of ezrin expression in pancreatic ductal carcinoma samples
Gene_expression (expression) of ezrin associated with pancreatic ductal carcinoma
1) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.49 Pain Relevance 0.04
We found that ezrin expression was not correlated with histological grading, pathologic stage, lymph node status or the depth of invasion (Table 2).


Gene_expression (expression) of ezrin in lymph node
2) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.14 Pain Relevance 0.18
These results indicated that ezrin expression level is closely associated with malignant progression of cancer.
Gene_expression (expression) of ezrin associated with malignant neoplastic disease and cancer
3) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.23 Pain Relevance 0
In addition, immunoflurescence staining using the VSV-G-tagged ezrin antibody further confirmed its stable overexpression in the MiaPaCa-2 cells (Figure 1D, E), which also showed that ezrin protein expression was dramatically decreased in the Mia ezsi-E cells (Figure 1G) compared to that in the Mia ezsi-scam cells (Figure 1F).


Gene_expression (expression) of ezrin protein in E cells
4) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0 Pain Relevance 0
In this study, we investigated the effect of ezrin on the motility and invasion ability of the pancreatic cancer cell line MiaPaCa-2, as well as the expression of ezrin in pancreatic duct adenocarcinoma, chronic pancreatitis and normal pancreatic tissues.


Gene_expression (expression) of ezrin in pancreatic duct associated with adenocarcinoma, pancreatic cancer and chronic pancreatitis
5) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.23 Pain Relevance 0.10
Ezrin was not detectable in normal pancreatic ducts and acini (Figure 7A); however, 64 PDAC samples were found to be ezrin positive (91.4%, 64/70) (Figure 7B-D, Table 2), suggesting that ezrin was overexpressed in human PDAC and that ezrin expression was likely associated with pancreatic cancer development.
Gene_expression (expression) of ezrin in pancreatic ducts associated with adenocarcinoma and pancreatic cancer
6) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.32 Pain Relevance 0.10
Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.
Gene_expression (overexpressing) of ezrin in lymph node associated with pancreatic cancer and metastasis
7) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0
Ezrin was also expressed in intercalated ducts adjacent to the adenocarcinoma, which has been considered to be the origin of ducts and acini, as well as the starting point of pancreatic ductal carcinoma development.


Gene_expression (expressed) of Ezrin in ducts associated with adenocarcinoma and pancreatic ductal carcinoma
8) Confidence 0.77 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.46 Pain Relevance 0.19
Patients with pancreatic ductal adenocarcinoma (PDAC) with membranous ezrin expression exhibited poorer prognosis compared to those without membranous ezrin expression, and ERM protein was more likely to be present in poorly differentiated cancers [23-26].
Gene_expression (expression) of ezrin associated with adenocarcinoma and cancer
9) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.68 Pain Relevance 0
In pancreatic carcinomas, a high-level ezrin expression is associated with high metastatic potential; membrane translocation of ezrin might play a role in the progression from borderline tumor to malignant transformation.
Gene_expression (expression) of ezrin associated with malignant neoplastic disease, cancer and pancreatic cancer
10) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.75 Pain Relevance 0
Patients with pancreatic ductal adenocarcinoma (PDAC) with membranous ezrin expression exhibited poorer prognosis compared to those without membranous ezrin expression, and ERM protein was more likely to be present in poorly differentiated cancers [23-26].
Gene_expression (expression) of ezrin associated with adenocarcinoma and cancer
11) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.75 Pain Relevance 0
Ezrin overexpression also increased the number of metastatic foci (6/8 vs. 1/8) in a spontaneous metastasis nude mouse model.
Gene_expression (overexpression) of Ezrin associated with metastasis
12) Confidence 0.77 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.18 Pain Relevance 0.13
A striking feature of ezrin overexpression was the increased formation of surface protrusions that play essential roles in cell motility [37].
Gene_expression (overexpression) of ezrin
13) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.54 Pain Relevance 0
Ezrin overexpression inducing Erk1/2 activation
Gene_expression (overexpression) of Ezrin
14) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.27 Pain Relevance 0
Our results showed that ezrin overexpression increased the level of phosphorylated-Erk1/2 protein without altering the level of total Erk1/2 in MiaPaCa-2 cells.
Gene_expression (overexpression) of ezrin
15) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.32 Pain Relevance 0
To study the function of the Vil2 gene in MiaPaCa-2 cells, the pcb6-ezrin-VSV-G vector was adopted to stably overexpress the ezrin protein, and the pcb6 vector was used as a control.
Gene_expression (overexpress) of ezrin protein
16) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.30 Pain Relevance 0
Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).


Gene_expression (overexpression) of ezrin
17) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.73 Pain Relevance 0
Ezrin was not detectable in normal pancreatic ducts and acini (Figure 7A); however, 64 PDAC samples were found to be ezrin positive (91.4%, 64/70) (Figure 7B-D, Table 2), suggesting that ezrin was overexpressed in human PDAC and that ezrin expression was likely associated with pancreatic cancer development.
Gene_expression (overexpressed) of ezrin in pancreatic ducts associated with adenocarcinoma and pancreatic cancer
18) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.34 Pain Relevance 0.09
Ezrin overexpression enhancing the formation of cell protrusions and cell microvilli
Gene_expression (overexpression) of Ezrin
19) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0 Pain Relevance 0
Ezrin overexpression promoting metastasis of MiaPaCa-2 cells in vivo
Gene_expression (overexpression) of Ezrin associated with metastasis
20) Confidence 0.77 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.76 Pain Relevance 0

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