INT325931

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.57
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
E cells 4
lung 2
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 6 84.64 Quite High
Chronic pancreatitis 66 40.84 Quite Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Ductal Carcinoma 18 99.84 Very High Very High Very High
Cancer 162 98.68 Very High Very High Very High
Malignant Neoplastic Disease 30 97.80 Very High Very High Very High
Metastasis 246 97.64 Very High Very High Very High
Osteogenic Sarcomas 12 96.76 Very High Very High Very High
Pancreatic Cancer 132 94.40 High High
Gastrointestinal Stromal Tumor 6 94.00 High High
Adenocarcinoma 162 89.60 High High
Rhabdomyosarcoma 12 86.36 High High
Anaplastic Astrocytoma 6 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also shown that ezrin protein expression was efficiently decreased by 70.5% and 90.1% in the Mia ezsi-B and Mia ezsi-E cells, respectively, compared to that in the Mia ezsi-scram cells (Figure 1C).
Negative_regulation (decreased) of Gene_expression (expression) of ezrin protein in E cells
1) Confidence 0.58 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0 Pain Relevance 0
Consistent with these reports, suppression of ezrin protein expression and disruption of its function significantly reduced lung metastasis in a mouse osteosarcoma model [19].
Negative_regulation (suppression) of Gene_expression (expression) of ezrin protein in lung associated with osteogenic sarcomas and metastasis
2) Confidence 0.58 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.38 Pain Relevance 0
In addition, immunoflurescence staining using the VSV-G-tagged ezrin antibody further confirmed its stable overexpression in the MiaPaCa-2 cells (Figure 1D, E), which also showed that ezrin protein expression was dramatically decreased in the Mia ezsi-E cells (Figure 1G) compared to that in the Mia ezsi-scam cells (Figure 1F).


Negative_regulation (decreased) of Gene_expression (expression) of ezrin protein in E cells
3) Confidence 0.58 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0 Pain Relevance 0
Establishment of ezrin overexpression monoclones and silencing of the ezrin gene in MiaPaCa-2 cells
Negative_regulation (Establishment) of Gene_expression (overexpression) of ezrin
4) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.34 Pain Relevance 0
Immunohistochemical analysis of ezrin expression in pancreatic ductal carcinoma samples
Negative_regulation (analysis) of Gene_expression (expression) of ezrin associated with pancreatic ductal carcinoma
5) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.50 Pain Relevance 0.04
Establishment of ezrin overexpression monoclones and silencing of the ezrin gene in MiaPaCa-2 cells
Negative_regulation (Establishment) of Gene_expression (silencing) of ezrin gene
6) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.34 Pain Relevance 0

General Comments

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