INT325934

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.78
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
plasma 1
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 44 99.84 Very High Very High Very High
metalloproteinase 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 44 99.84 Very High Very High Very High
Melanoma 8 99.84 Very High Very High Very High
Adenocarcinoma 108 99.52 Very High Very High Very High
Pancreatic Cancer 88 98.26 Very High Very High Very High
Cancer 108 97.84 Very High Very High Very High
Malignant Neoplastic Disease 20 97.48 Very High Very High Very High
Metastasis 164 94.64 High High
Breast Cancer 8 87.40 High High
Osteogenic Sarcomas 8 80.96 Quite High
Apoptosis 4 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pancreatic carcinomas, a high-level ezrin expression is associated with high metastatic potential; membrane translocation of ezrin might play a role in the progression from borderline tumor to malignant transformation.
Localization (translocation) of ezrin associated with malignant neoplastic disease, cancer and pancreatic cancer
1) Confidence 0.80 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.70 Pain Relevance 0
In melanoma cells, ezrin has been shown to be localized in phagocytic vacuoles, suggesting that its association with the actin cytoskeleton is crucial for the phagocytic activity [15].
Localization (localized) of ezrin associated with melanoma
2) Confidence 0.80 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.58 Pain Relevance 0
Because CP is also an independent risk factor for PDAC development [41], high ezrin expression proportion in CP and PanINs suggests that ezrin might be involved in the earliest stages of PDAC pathogenesis and could potentially serve as an indicator for those lesions progressing to the more advanced stage--PDAC.
Localization (proportion) of ezrin associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.75 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.15 Pain Relevance 0.27
Phosphorylation of ezrin induces its translocation from the cytoplasm to the plasma membranes of microvillus and confers the ability of binding to plasma membrane and actin filaments [9-12].
Localization (translocation) of ezrin in plasma
4) Confidence 0.70 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.35 Pain Relevance 0

General Comments

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