INT325939

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.27
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
lymph node 2
ducts 2
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 66 100.00 Very High Very High Very High
Spinal cord 6 47.24 Quite Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 66 100.00 Very High Very High Very High
Malignant Neoplastic Disease 30 98.92 Very High Very High Very High
Adenocarcinoma 162 98.48 Very High Very High Very High
Breast Cancer 12 98.32 Very High Very High Very High
Metastasis 246 97.98 Very High Very High Very High
Pancreatic Cancer 132 96.98 Very High Very High Very High
Osteogenic Sarcomas 12 91.88 High High
Cancer 162 82.40 Quite High
Gastrointestinal Stromal Tumor 6 77.52 Quite High
Adhesions 18 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).


Neg (no) Regulation (changes) of Gene_expression (overexpression) of ezrin
1) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.74 Pain Relevance 0
Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.
Regulation (change) of Gene_expression (overexpressing) of ezrin in lymph node associated with pancreatic cancer and metastasis
2) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0
Ezrin expression in the tubular complexes in CP and PanIN, as well as in the proliferated intercalated ducts in the pancreatic tissue adjacent to PDAC
Regulation (ducts) of Gene_expression (expression) of Ezrin in ducts associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.11 Pain Relevance 0.19
Taken together, the observed effects of ezrin overexpression and silencing on the cell malignant transformation indicate a role for ezrin in regulating tumor metastasis and progression [22].
Regulation (effects) of Gene_expression (overexpression) of ezrin associated with malignant neoplastic disease and metastasis
4) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.65 Pain Relevance 0
Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).


Neg (no) Regulation (changes) of Gene_expression (silencing) of ezrin
5) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.73 Pain Relevance 0
Moreover, there were no obvious changes in the protein levels of Akt, phosphorylated-Akt and phosphorylated-ezrin (Tyr353) in both the ezrin silencing and the ezrin overexpression clones of MiaPaCa-2 cells (Figure 6).


Neg (no) Regulation (changes) of Gene_expression (levels) of phosphorylated-ezrin
6) Confidence 0.39 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.66 Pain Relevance 0

General Comments

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