INT325940

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 27.79
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
lymph node 8
B cells 4
pancreatic ducts 2
ducts 2
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 451 100.00 Very High Very High Very High
Spinal cord 41 92.88 High High
metalloproteinase 41 69.28 Quite High
agonist 16 50.96 Quite High
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
noradrenaline 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 451 100.00 Very High Very High Very High
Adenocarcinoma 1107 99.84 Very High Very High Very High
Metastasis 1681 99.72 Very High Very High Very High
Osteogenic Sarcomas 82 99.56 Very High Very High Very High
Pancreatic Cancer 902 99.52 Very High Very High Very High
Rhabdomyosarcoma 82 99.16 Very High Very High Very High
Cancer 1107 99.12 Very High Very High Very High
Malignant Neoplastic Disease 205 98.92 Very High Very High Very High
Pancreatic Ductal Carcinoma 123 98.68 Very High Very High Very High
Breast Cancer 82 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ezrin overexpression enhancing the formation of cell protrusions and cell microvilli
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ezrin
1) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0 Pain Relevance 0
Ezrin was not detectable in normal pancreatic ducts and acini (Figure 7A); however, 64 PDAC samples were found to be ezrin positive (91.4%, 64/70) (Figure 7B-D, Table 2), suggesting that ezrin was overexpressed in human PDAC and that ezrin expression was likely associated with pancreatic cancer development.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ezrin in pancreatic ducts associated with adenocarcinoma and pancreatic cancer
2) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.34 Pain Relevance 0.09
Ezrin overexpression may be sufficient to confer metastatic potential [38], and ezrin silencing may reverse metastatic behavior, through other ways [21].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ezrin
3) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.43 Pain Relevance 0.06
Ezrin overexpression has also been considered as an independent predictor of adverse outcome of gastrointestinal stromal tumors [18].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ezrin associated with gastrointestinal stromal tumor
4) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.12 Pain Relevance 0
Furthermore, ezrin overexpression activated Erk1/2 in MiaPaCa-2 cells, which might be partially related to the alteration of cell morphology and invasion.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin
5) Confidence 0.69 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.31 Pain Relevance 0.15
Our results showed that ezrin overexpression increased the level of phosphorylated-Erk1/2 protein without altering the level of total Erk1/2 in MiaPaCa-2 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin
6) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.32 Pain Relevance 0
These data indicate that ezrin overexpression can induce metastasis in vivo in spontaneous metastasis mice models; however, ezrin silencing had no obvious effect on the metastatic potential of MiaPaCa-2 cells.


Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin associated with metastasis
7) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.54 Pain Relevance 0.05
To study the function of the Vil2 gene in MiaPaCa-2 cells, the pcb6-ezrin-VSV-G vector was adopted to stably overexpress the ezrin protein, and the pcb6 vector was used as a control.
Positive_regulation (overexpress) of Gene_expression (overexpress) of ezrin protein
8) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.30 Pain Relevance 0
Western blot analysis showed that ezrin protein expression was efficiently increased by 3.8 folds in the Mia ez22-B cells compared to the Mia pcb6 cells (Figure 1A, B).
Positive_regulation (increased) of Gene_expression (expression) of ezrin protein in B cells
9) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0 Pain Relevance 0
We found that ezrin overexpression promoted cell protrusion, microvillus formation, anchorage-independent growth, motility and invasion in a pancreatic cancer cell line, MiaPaCa-2, whereas ezrin silencing resulted in the opposite effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin associated with pancreatic cancer
10) Confidence 0.69 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 0.98 Pain Relevance 0
Taken together, the observed effects of ezrin overexpression and silencing on the cell malignant transformation indicate a role for ezrin in regulating tumor metastasis and progression [22].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin associated with malignant neoplastic disease and metastasis
11) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.64 Pain Relevance 0
Immunohistochemical analysis demonstrated that ezrin expression was elevated in PDAC samples compared to normal pancreatic tissues, which provided additional evidence supporting a functional role of ezrin in pancreatic cancer development.
Positive_regulation (elevated) of Gene_expression (expression) of ezrin associated with adenocarcinoma and pancreatic cancer
12) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.49 Pain Relevance 0.08
A striking feature of ezrin overexpression was the increased formation of surface protrusions that play essential roles in cell motility [37].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin
13) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.54 Pain Relevance 0
Ezrin overexpression also increased the number of metastatic foci (6/8 vs. 1/8) in a spontaneous metastasis nude mouse model.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ezrin associated with metastasis
14) Confidence 0.69 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.18 Pain Relevance 0.13
Ezrin overexpression inducing Erk1/2 activation
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ezrin
15) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.27 Pain Relevance 0
Ezrin overexpression promoting metastasis of MiaPaCa-2 cells in vivo
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ezrin associated with metastasis
16) Confidence 0.69 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.76 Pain Relevance 0
Immunohistochemical analysis showed that ezrin was overexpressed in pancreatic ductal adenocarcinoma (PDAC) (91.4%) and precancerous lesions, i.e. the tubular complexes in chronic pancreatitis (CP) and pancreatic intraepithelial neoplasm (PanIN) (85.7% and 97.1%, respectively), compared to normal pancreatic tissues (0%).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ezrin associated with adenocarcinoma, carcinoma in situ and chronic pancreatitis
17) Confidence 0.69 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.42 Pain Relevance 0.19
Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of pEzrin in lymph node associated with pancreatic cancer and metastasis
18) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.27 Pain Relevance 0
Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ezrin in lymph node associated with pancreatic cancer and metastasis
19) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0
Establishment of ezrin overexpression monoclones and silencing of the ezrin gene in MiaPaCa-2 cells
Positive_regulation (overexpression) of Gene_expression (overexpression) of ezrin
20) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.34 Pain Relevance 0

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