INT32595

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 6.55
Pain Relevance 12.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
NK cell 10
lymphocyte 8
T cells 6
spleen 4
PSC 2
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 64 100.00 Very High Very High Very High
Dynorphin 29 99.94 Very High Very High Very High
substance P 16 99.80 Very High Very High Very High
Kappa opioid receptor 3 99.80 Very High Very High Very High
narcan 42 99.76 Very High Very High Very High
qutenza 12 99.26 Very High Very High Very High
antagonist 27 99.06 Very High Very High Very High
Enkephalin 20 98.92 Very High Very High Very High
alcohol 9 98.56 Very High Very High Very High
electroacupuncture 13 98.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 85 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.46 Very High Very High Very High
Frailty 4 99.44 Very High Very High Very High
Disease 13 99.40 Very High Very High Very High
Necrosis 8 99.36 Very High Very High Very High
Cancer 14 99.00 Very High Very High Very High
Pancreatitis 10 97.02 Very High Very High Very High
Brain Injury 21 96.92 Very High Very High Very High
Photosensitivity Disorders 2 94.20 High High
Urological Neuroanatomy 17 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the high VE diet induced a significant increase in interleukin 2 (IL2) production from splenocytes in both young rats and old rats following in vitro stimulation with Con A for 48 h.
Positive_regulation (induced) of Gene_expression (production) of interleukin 2
1) Confidence 0.70 Published 1997 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 9151245 Disease Relevance 0.07 Pain Relevance 0.05
The NK cell activity, the spleen lymphocyte proliferation and the induction of IL-2 production were all significantly inhibited following traumatization.
Positive_regulation (induction) of Gene_expression (production) of IL-2 in NK cell
2) Confidence 0.70 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.07 Pain Relevance 0.52
Compared to the traumatic group, the inhibition of the NK cell activity and the induction of IL-2 production were antagonised by icv injection of naloxone.
Positive_regulation (induction) of Gene_expression (production) of IL-2 in NK cell associated with narcan
3) Confidence 0.70 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.09 Pain Relevance 0.54
The present study was undertaken to examine the effects of intracerebroventricular (icv) injection of naloxone (an antagonist of opioid receptors) and electroacupuncture (EA) on the natural killer (NK) cell activity, lymphocyte proliferation and induction of interleukin-2 (IL-2) production of spleen lymphocytes of surgically traumatized rats.
Positive_regulation (induction) of Gene_expression (production) of IL-2 in lymphocyte associated with antagonist, narcan, opioid receptor, electroacupuncture and intracerebroventricular
4) Confidence 0.70 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.06 Pain Relevance 0.46
Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes.
Positive_regulation (enhances) of Gene_expression (production) of interleukin-2 associated with dynorphin
5) Confidence 0.69 Published 1999 Journal Neuropeptides Section Title Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.68
In this work we found that xylazine administered in vivo at a dose of 2.5 mg/kg enhanced spleen cell proliferation and interleukin 2 (IL-2) production in cultures stimulated with concanavalin A (Con A), whereas doses of 10 and 25 mg/kg were inhibitory.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in spleen
6) Confidence 0.69 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.05 Pain Relevance 0.30
Furthermore, the high VE diet induced a significant increase in interleukin 2 (IL2) production from splenocytes in both young rats and old rats following in vitro stimulation with Con A for 48 h.
Positive_regulation (increase) of Gene_expression (production) of IL2
7) Confidence 0.50 Published 1997 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 9151245 Disease Relevance 0.07 Pain Relevance 0.05
The present study was undertaken to examine the effects of intracerebroventricular (icv) injection of naloxone (an antagonist of opioid receptors) and electroacupuncture (EA) on the natural killer (NK) cell activity, lymphocyte proliferation and induction of interleukin-2 (IL-2) production of spleen lymphocytes of surgically traumatized rats.
Positive_regulation (induction) of Gene_expression (production) of interleukin-2 in lymphocyte associated with antagonist, narcan, opioid receptor, electroacupuncture and intracerebroventricular
8) Confidence 0.50 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.06 Pain Relevance 0.46
In this work we found that xylazine administered in vivo at a dose of 2.5 mg/kg enhanced spleen cell proliferation and interleukin 2 (IL-2) production in cultures stimulated with concanavalin A (Con A), whereas doses of 10 and 25 mg/kg were inhibitory.
Positive_regulation (enhanced) of Gene_expression (production) of interleukin 2 in spleen
9) Confidence 0.50 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.05 Pain Relevance 0.30
None of these treatments resulted in detectable alterations in IL-2 production after 48 h in culture.
Positive_regulation (alterations) of Gene_expression (production) of IL-2
10) Confidence 0.49 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.47
Furthermore, the high VE diet induced a significant increase in interleukin 2 (IL2) production from splenocytes in both young rats and old rats following in vitro stimulation with Con A for 48 h.
Positive_regulation (increase) of Gene_expression (production) of interleukin 2
11) Confidence 0.47 Published 1997 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 9151245 Disease Relevance 0.07 Pain Relevance 0.05
These behavioral data are compatible with the data for IL-2 levels, which showed that IL-2 levels in the cerebral cortex of HA OVX rats were significantly decreased by all three dosages of dioscorea, while IL-2 levels in the prefrontal cortex of LA OVX rats were increased by dioscorea at 250 mg/kg/day.
Positive_regulation (increased) of in cortex Gene_expression (levels) of IL-2 in prefrontal associated with anxiety disorder and cerebral cortex
12) Confidence 0.46 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.12 Pain Relevance 0.15
The results showed that dynorphin A 1-13 as well as dynorphin A 1-17 enhanced concanavalin A-stimulated [(3)H] thymidine uptake 46-112% and IL-2 production in a dose-dependent fashion.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 associated with dynorphin
13) Confidence 0.46 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.66
The data suggest that dynorphin A enhanced mitogen-stumulated lymphocyte proliferation and IL-2 production via kappa-opioid receptor and cAMP pathway.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in lymphocyte associated with dynorphin and kappa opioid receptor
14) Confidence 0.46 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.64
SP administration stimulates Con A-induced proliferation of spleen and peripheral blood lymphocytes from normal and neonatally capsaicin treated rats, which correlated with enhanced IL-2 production and expression of activation antigens such as IL-2 receptor alpha chain (CD25) and RT1B MHC class II molecule.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in blood associated with qutenza and substance p
15) Confidence 0.46 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.68
AChE mAb treatment increased the mitogen-stimulated proliferation of splenic T cells and interleukin-2 (IL-2) production by stimulated splenocytes, indicating that these immune measures are sensitive to the AChE mAb-induced alteration in sympathetic function.
Positive_regulation (increased) of Gene_expression (production) of interleukin-2 in T cells
16) Confidence 0.43 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417803 Disease Relevance 0 Pain Relevance 0.39
The same tendency was observed on the induction of IL-2 production.
Positive_regulation (induction) of Gene_expression (production) of IL-2
17) Confidence 0.37 Published 2000 Journal Acupunct Electrother Res Section Abstract Doc Link 10830970 Disease Relevance 0.26 Pain Relevance 0.98
The levels of TNF-alpha, IL-1 and IL-2 in the serum of AA rats were increased, whereas the level of IL-10 was decreased.
Positive_regulation (increased) of Gene_expression (levels) of IL-2
18) Confidence 0.36 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.21 Pain Relevance 0
Naltrexone administration increased the production of IL-2, IL-4, and IL-6 and the basal and cytokine-activated NK cell cytolytic activity and IFN-gamma production in the splenocytes of pair-fed and alcohol-fed rats.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in NK cell associated with alcohol and cytokine
19) Confidence 0.34 Published 2010 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 19929573 Disease Relevance 0.09 Pain Relevance 0.64
Naltrexone administration increased the production of IL-2, IL-4, and IL-6 and the basal and cytokine-activated NK cell cytolytic activity and IFN-gamma production in the splenocytes of pair-fed and alcohol-fed rats.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in NK cell associated with alcohol and cytokine
20) Confidence 0.34 Published 2010 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 19929573 Disease Relevance 0.09 Pain Relevance 0.63

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