INT325952

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ezr, Mapk1) cytosol (Ezr, Mapk1) cytoskeleton (Ezr, Mapk1)
nucleoplasm (Mapk1) mitochondrion (Mapk1) intracellular (Ezr)
Ezr (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 22 77.84 Quite High
metalloproteinase 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 82 98.72 Very High Very High Very High
Cancer 54 98.52 Very High Very High Very High
Pancreatic Cancer 44 91.20 High High
Adhesions 6 88.36 High High
Adenocarcinoma 54 84.72 Quite High
Stress 2 84.16 Quite High
Pancreatitis 22 77.84 Quite High
Disease 4 76.60 Quite High
Carcinoma In Situ 2 74.56 Quite High
Pancreatic Ductal Carcinoma 6 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that ezrin overexpression increased the level of phosphorylated-Erk1/2 protein without altering the level of total Erk1/2 in MiaPaCa-2 cells.
Gene_expression (overexpression) of ezrin Positive_regulation (increased) of Erk1/2
1) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0
Furthermore, ezrin overexpression activated Erk1/2 in MiaPaCa-2 cells, which might be partially related to the alteration of cell morphology and invasion.
Gene_expression (overexpression) of ezrin Positive_regulation (activated) of Erk1/2
2) Confidence 0.02 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2916894 Disease Relevance 1.32 Pain Relevance 0.15

General Comments

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