INT32596

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Context Info
Confidence 0.61
First Reported 1987
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 13
Total Number 20
Disease Relevance 6.85
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
NK cell 9
spinal cord 4
spleen 4
T cell 4
cerebral cortex 3
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 40 100.00 Very High Very High Very High
Central grey 29 100.00 Very High Very High Very High
cytokine 23 100.00 Very High Very High Very High
substance P 4 99.84 Very High Very High Very High
Dynorphin 14 99.80 Very High Very High Very High
cerebral cortex 27 98.80 Very High Very High Very High
Clonidine 2 98.08 Very High Very High Very High
Spinal cord 35 96.64 Very High Very High Very High
narcan 24 96.04 Very High Very High Very High
Pain threshold 4 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 36 100.00 Very High Very High Very High
Sepsis 49 97.68 Very High Very High Very High
Injury 100 97.40 Very High Very High Very High
Death 36 97.04 Very High Very High Very High
Pain 7 95.84 Very High Very High Very High
Targeted Disruption 6 95.20 Very High Very High Very High
Apoptosis 66 93.12 High High
Anxiety Disorder 255 91.84 High High
INFLAMMATION 22 66.56 Quite High
Hypertrophy 3 61.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments were undertaken in rats to investigate the effects of in vivo infusion of beta-endorphin (BEP) on subsequent Con A-induced proliferation and interleukin 2 (IL-2) production by spleen cells in vitro.
Spec (investigate) Regulation (effects) of Gene_expression (production) of IL-2 in spleen
1) Confidence 0.61 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.29
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Spec (investigated) Regulation (effects) of Gene_expression (production) of IL-2 in NK cell associated with central grey and morphine
2) Confidence 0.56 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.43 Pain Relevance 0.56
Pawlak et al [6] reported that striatal microinjection of IL-2 affects emotional behavior in the EPM test.
Regulation (affects) of Gene_expression (microinjection) of IL-2
3) Confidence 0.45 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.58 Pain Relevance 0.03
In this study, we investigated dynorphin A in the regulation of mitogen-induced proliferation and and interleukin-2 (IL-2) production of rat splenocytes.
Spec (investigated) Regulation (regulation) of Gene_expression (production) of IL-2 associated with dynorphin
4) Confidence 0.45 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.63
In this study, we investigated dynorphin A in the regulation of mitogen-induced proliferation and and interleukin-2 (IL-2) production of rat splenocytes.
Spec (investigated) Regulation (regulation) of Gene_expression (production) of interleukin-2 associated with dynorphin
5) Confidence 0.45 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.63
Experiments were undertaken in rats to investigate the effects of in vivo infusion of beta-endorphin (BEP) on subsequent Con A-induced proliferation and interleukin 2 (IL-2) production by spleen cells in vitro.
Spec (investigate) Regulation (effects) of Gene_expression (production) of interleukin 2 in spleen
6) Confidence 0.44 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.29
AIM: To study the effects of intra-hippocampal injection of interleukin-2 (IL-2) on the substance P-like immunoreactivity (SP-LI) in both periaqueductal gray (PAG) and spinal cord, and on pain threshold in rats.
Regulation (effects) of Gene_expression (injection) of interleukin-2 in spinal cord associated with pain threshold, urological neuroanatomy, central grey, spinal cord and substance p
7) Confidence 0.44 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 11245094 Disease Relevance 0.44 Pain Relevance 0.43
AIM: To study the effects of intra-hippocampal injection of interleukin-2 (IL-2) on the substance P-like immunoreactivity (SP-LI) in both periaqueductal gray (PAG) and spinal cord, and on pain threshold in rats.
Regulation (effects) of Gene_expression (injection) of IL-2 in spinal cord associated with pain threshold, urological neuroanatomy, central grey, spinal cord and substance p
8) Confidence 0.44 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 11245094 Disease Relevance 0.44 Pain Relevance 0.43
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of IL-2 in mesencephalon associated with central grey and morphine
9) Confidence 0.41 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of IL-2 in mesencephalon associated with central grey and morphine
10) Confidence 0.41 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Spec (investigated) Regulation (effects) of Gene_expression (production) of interleukin-2 in NK cell associated with central grey and morphine
11) Confidence 0.41 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.43 Pain Relevance 0.56
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of IL-2 in mesencephalon associated with central grey and morphine
12) Confidence 0.41 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
In the mesenteric lymph nodes, DMPP had no effect on mitogenic responsiveness, the production of IL-2 or the total number of leukocytes.
Neg (no) Regulation (effect) of Gene_expression (production) of IL-2 in mesenteric lymph nodes
13) Confidence 0.38 Published 1993 Journal Brain Behav. Immun. Section Abstract Doc Link 8219413 Disease Relevance 0 Pain Relevance 0.26
The AChE mAb-induced alteration in sympathetic activity did not affect the suppressive effects of acute morphine treatment on the mitogen-stimulated proliferative response of splenic T and B cells and blood T cells, splenic NK cell activity, and the production of IFN-gamma and IL-2 by stimulated splenocytes.
Neg (not) Regulation (affect) of Gene_expression (production) of IL-2 in NK cell associated with morphine
14) Confidence 0.38 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417803 Disease Relevance 0 Pain Relevance 0.31
As shown in Table 5, none of the dosages of dioscorea used affected IL-2 levels in the prefrontal cortex and cerebral cortex in sham-operated rats.
Regulation (affected) of Gene_expression (levels) of IL-2 in cerebral cortex associated with cerebral cortex
15) Confidence 0.27 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.61 Pain Relevance 0.34
A similar stimulatory (10 microM) and inhibitory (50-500 microM) effect on splenocyte proliferation and IL-2 production was observed in vitro.
Regulation (effect) of Gene_expression (production) of IL-2
16) Confidence 0.27 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.14 Pain Relevance 0.35
None of these treatments resulted in detectable alterations in IL-2 production after 48 h in culture.
Regulation (alterations) of Gene_expression (production) of IL-2
17) Confidence 0.27 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.47
Our previous studies 17, 18 determined IL-2 production and proliferation responses in MLN CD4+ T cells cocultured with same MLN's APCs harvested from sham, thermal injury, sepsis, and TI+sepsis animals sacrificed on days 3 post-injury.
Spec (determined) Regulation (responses) of Spec (determined) Gene_expression (production) of IL-2 in T cells associated with injury and sepsis
18) Confidence 0.23 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.67 Pain Relevance 0
As shown in Table 5, none of the dosages of dioscorea used affected IL-2 levels in the prefrontal cortex and cerebral cortex in sham-operated rats.
Regulation (affected) of in cortex Gene_expression (levels) of IL-2 in cerebral cortex associated with cerebral cortex
19) Confidence 0.09 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.61 Pain Relevance 0.34
The NAADP/Ca2+ signalling pathway seems to control this decision, since expression of the major cytokine involved in T cell proliferation, interleukin-2, depends on a full, NAADP-initiated Ca2+ response.
Regulation (depends) of Gene_expression (expression) of interleukin-2 in T cell associated with cytokine
20) Confidence 0.02 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.16 Pain Relevance 0.12

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