INT325972

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc6a1)
Slc6a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 15 99.96 Very High Very High Very High
gABA 5 99.04 Very High Very High Very High
substance P 1 98.96 Very High Very High Very High
Opioid 12 97.20 Very High Very High Very High
opiate 2 96.68 Very High Very High Very High
tolerance 13 96.40 Very High Very High Very High
Morphine 9 94.80 High High
Neurotransmitter 7 91.24 High High
psychological dependence 1 89.64 High High
GABAergic 2 87.52 High High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 1 99.96 Very High Very High Very High
Opiate Addiction 8 96.48 Very High Very High Very High
Drug Dependence 15 89.64 High High
Alcohol Addiction 4 89.36 High High
Targeted Disruption 6 75.08 Quite High
Convulsion 1 43.92 Quite Low
Recurrence 5 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Cannabis Dependence 1 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GAT-1 may be a target for therapy to reduce withdrawal symptoms.[11] Substance P (SP) was also seen to modulate expression of opiate tolerance and withdrawal in rodents.[12]


Negative_regulation (reduce) of GAT-1 Binding (target) of associated with tolerance, opiate, withdrawal and substance p
1) Confidence 0.02 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.52 Pain Relevance 2.38

General Comments

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