INT325976

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ifi30) plasma membrane (Ifi30) lysosome (Ifi30)
Anatomy Link Frequency
gill 2
Ifi30 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
Nucleus accumbens 5 100.00 Very High Very High Very High
Glutamate 4 100.00 Very High Very High Very High
orphanin 5 98.32 Very High Very High Very High
withdrawal 15 97.08 Very High Very High Very High
narcan 1 95.76 Very High Very High Very High
psychological dependence 1 95.68 Very High Very High Very High
Neurotransmitter 7 93.76 High High
tolerance 13 93.64 High High
Analgesic 1 93.24 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 98.68 Very High Very High Very High
Drug Dependence 15 95.68 Very High Very High Very High
Opiate Addiction 8 77.12 Quite High
Substance Withdrawal Syndrome 1 65.20 Quite High
Alcohol Addiction 4 54.64 Quite High
Neuroblastoma 1 21.76 Low Low
Convulsion 1 9.20 Low Low
Recurrence 5 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Cannabis Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of gill glutamate transporter, gamma interferon-inducible lysosomal thiol reductase (GILT-1) mRNA was found to be increased in the striatum and NAc of morphine-dependent rats and decreased in morphine-withdrawn rats.[9] A glutamate transporter activator inhibited the development of physical and psychological dependence on morphine.[9]

Other neurotransmitter systems

Negative_regulation (decreased) of Gene_expression (Expression) of gamma interferon-inducible lysosomal thiol reductase in gill associated with nucleus accumbens, neurotransmitter, glutamate, psychological dependence and morphine
1) Confidence 0.19 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.56 Pain Relevance 2.78

General Comments

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