INT32603

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Context Info
Confidence 0.14
First Reported 1988
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.08
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MIA3)
Anatomy Link Frequency
Plasma 1
sensory nerve 1
MIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 9 99.80 Very High Very High Very High
Calcitonin gene-related peptide 1 98.44 Very High Very High Very High
substance P 3 97.00 Very High Very High Very High
Neuropeptide 2 97.00 Very High Very High Very High
c fibre 7 94.28 High High
chemokine 6 94.00 High High
dorsal root ganglion 1 91.08 High High
diabetic neuropathy 115 90.16 High High
neurotrophin 3 2 89.72 High High
Nerve growth factor 18 88.92 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 311 99.84 Very High Very High Very High
Congenital Anomalies 55 99.60 Very High Very High Very High
Cancer 4 99.40 Very High Very High Very High
Pancreatic Cancer 8 99.28 Very High Very High Very High
Metastasis 3 98.04 Very High Very High Very High
Nociception 23 97.48 Very High Very High Very High
Neuropathy 81 94.44 High High
Obesity 7 94.40 High High
Cirrhosis 2 94.36 High High
Renal Disease 2 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma insulin and C-peptide concentrations remained low and rebounded at the end of the infusions.
C-peptide Binding (rebounded) of in Plasma
1) Confidence 0.14 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2969000 Disease Relevance 0.25 Pain Relevance 0
C-peptide binds
C-peptide Binding (binds) of
2) Confidence 0.10 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.79 Pain Relevance 0.05
was statistically significantly greater in the group receiving C-peptide as compared to those receiving placebo (37% versus
C-peptide Binding (compared) of
3) Confidence 0.08 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.27 Pain Relevance 0.03
HRV was seen after 3 months of C-peptide replacement in type 1 diabetes patients
C-peptide Binding (replacement) of associated with diabetes mellitus
4) Confidence 0.08 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.72 Pain Relevance 0.04
subjects, it has been suggested that C-peptide could also exhibit biological
C-peptide Binding (exhibit) of
5) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.77 Pain Relevance 0
Interestingly, C-peptide does not exhibit any
C-peptide Neg (not) Binding (exhibit) of
6) Confidence 0.04 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.31 Pain Relevance 0.05
demonstrated specific binding of C-peptide to cell surfaces and suggested that
C-peptide Spec (suggested) Binding (binding) of
7) Confidence 0.00 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.64 Pain Relevance 0.07
It therefore appears that C-peptide interacts
C-peptide Binding (interacts) of
8) Confidence 0.00 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.17 Pain Relevance 0.09
From these findings we conclude that replacement of insulinomimetic C-peptide prevents abnormalities of neurotrophins, their receptors, and nociceptive neuropeptides in type 1 BB/Wor-rats, resulting in the prevention of C-fiber pathology and nociceptive sensory nerve dysfunction.
C-peptide Binding (replacement) of in sensory nerve associated with nociception, c fibre, congenital anomalies and neuropeptide
9) Confidence 0.00 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 1.22 Pain Relevance 0.89
It was increased in 6 of 30 pancreatic cancer patients; in these subjects it was correlated with alanine aminotransferase and C-peptide, but not with tumor diameter or the presence of metastases.
C-peptide Binding (correlated) of associated with cancer, pancreatic cancer and metastasis
10) Confidence 0.00 Published 1995 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 7787209 Disease Relevance 1.93 Pain Relevance 0.09
PC2 also cleaved at single basic residues, resulting in the formation of the C-peptide and Dyn A 1-8.
C-peptide Binding (formation) of associated with dynorphin
11) Confidence 0.00 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9422738 Disease Relevance 0 Pain Relevance 0.47

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