INT326067

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.22
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOA1, APOE) lipid metabolic process (APOA1, APOE) extracellular space (APOA1, APOE)
extracellular region (APOA1, APOE) plasma membrane (APOA1, APOE) aging (APOE)
Anatomy Link Frequency
macrophages 2
liver 2
adipocyte 2
BFA 2
APOA1 (Homo sapiens)
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 74.00 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 168 100.00 Very High Very High Very High
Obesity 408 99.88 Very High Very High Very High
Stress 8 94.76 High High
INFLAMMATION 32 74.00 Quite High
Atherosclerosis 56 68.08 Quite High
Cardiovascular Disease 32 32.32 Quite Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Overweight 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, apoA-I also stimulates the secretion of apolipoprotein E (apoE); this action is probably partially dependent on ABCA1 [4].
apoA-I Positive_regulation (stimulates) of Localization (secretion) of apoE associated with disorder of lipid metabolism
1) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.79 Pain Relevance 0
ApoA-I increases apoE secretion with minimal effect upon apoE gene expression
ApoA-I Positive_regulation (increases) of Localization (secretion) of apoE
2) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.38 Pain Relevance 0
Indeed, the activation of apoE secretion by apoA-I may not only lead to an optimum increase in the size of the HDLs, but also to an increase in the uptake of these particles by the liver via the apoB/E LDLR according to the amount of apoE present.
apoA-I Positive_regulation (activation) of Localization (secretion) of apoE in liver
3) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.45 Pain Relevance 0
In addition to increasing cholesterol efflux, apoA-I is known to activate apoE secretion, at least in macrophages.
apoA-I Positive_regulation (activate) of Localization (secretion) of apoE in macrophages
4) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.37 Pain Relevance 0
We show here that apoA-I strongly stimulates apoE secretion, suggesting that in pathological conditions, such as obesity, the combination of low HDL-c levels (carrying apoA-I) and oxidative stress contributes to a major reduction in adipocyte apoE secretion.
apoA-I Positive_regulation (stimulates) of Localization (secretion) of apoE in adipocyte associated with stress, obesity and disorder of lipid metabolism
5) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.80 Pain Relevance 0.07
In addition, apoA-I also stimulates the secretion of apolipoprotein E (apoE); this action is probably partially dependent on ABCA1 [4].
apoA-I Positive_regulation (stimulates) of Localization (secretion) of apolipoprotein E associated with disorder of lipid metabolism
6) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.79 Pain Relevance 0
In order to clarify how apoA-I increased the adipocyte secretion of apoE, we chose to use the Golgi secretion inhibitor, BFA.
apoA-I Positive_regulation (increased) of Localization (secretion) of apoE in BFA
7) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.35 Pain Relevance 0
Brefeldin A inhibits basal apoE secretion but not apoA-I induced apoE secretion
apoA-I Neg (not) Positive_regulation (induced) of Localization (secretion) of apoE
8) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.29 Pain Relevance 0

General Comments

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