INT326068

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (APOA1) small molecule metabolic process (APOA1) extracellular region (APOA1)
plasma membrane (APOA1) enzyme binding (APOA1) transmembrane transport (APOA1)
Anatomy Link Frequency
BFA 4
APOA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 306 90.88 High High
Disorder Of Lipid Metabolism 126 68.32 Quite High
Atherosclerosis 42 19.28 Low Low
Cardiovascular Disease 24 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Overweight 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, no data is currently available on the signalling pathways involved in the apoA-I induced secretion of apoE.
Positive_regulation (induced) of Localization (secretion) of apoA-I
1) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.33 Pain Relevance 0
Inhibition of HMG-CoA reductase by simvastatin has no effect on the apoA-I induced release of cholesterol (figure 4) suggesting that the increase in cholesterol in the cell medium derives from a cholesterol storage pool not related to a feed-back activation of HMG-CoA reductase.
Positive_regulation (induced) of Localization (release) of apoA-I
2) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.12 Pain Relevance 0
Moreover, treatment with PKA and adenylate cyclase inhibitors does not lead to a reduction in apoA-I induced cholesterol release (figure 2).
Positive_regulation (induced) of Localization (release) of apoA-I
3) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.38 Pain Relevance 0
Consequently, BFA has no effect upon the apoA-I stimulated release of cholesterol.


Positive_regulation (stimulated) of Localization (release) of apoA-I in BFA
4) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.24 Pain Relevance 0
ApoA-I induced cholesterol release is not linked to cholesterol synthesis
Positive_regulation (induced) of Localization (release) of ApoA-I
5) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.30 Pain Relevance 0
However, our results prove that neither the inhibitors of PKA, nor BFA are able to disturb the release of apoA-I induced cholesterol.
Positive_regulation (induced) of Localization (release) of apoA-I in BFA
6) Confidence 0.37 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.39 Pain Relevance 0

General Comments

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