INT326070

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
adipocyte 2
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 66.08 Quite High
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 153 99.58 Very High Very High Very High
Disorder Of Lipid Metabolism 63 85.20 High High
Stress 3 81.60 Quite High
INFLAMMATION 12 66.08 Quite High
Atherosclerosis 21 60.16 Quite High
Cardiovascular Disease 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Overweight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apoE is highly implicated in the regulation of lipid metabolism, in the expression of certain adipocyte genes, and in the proliferation of pre-adipocytes [7,27,28], with the secretion of apoE being controlled during adipocyte differentiation [29].
Regulation (controlled) of Localization (secretion) of apoE in adipocyte associated with obesity
1) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.69 Pain Relevance 0.03
The regulation of apoE secretion by apoA-I, is neither dependent upon an increase in gene transcription, nor upon increased release from the Golgi (figures 5 and 6).
Neg (neither) Regulation (dependent) of Localization (secretion) of apoE
2) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.18 Pain Relevance 0
Moreover, it is noteworthy that inhibition of adenylate cyclase or PKA does not modify the activator effect of apoA-I on apoE secretion (data not shown).
Neg (not) Regulation (modify) of Localization (secretion) of apoE
3) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.35 Pain Relevance 0

General Comments

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