INT326081

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
adipocyte 2
BFA 2
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 89.84 High High
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 99.52 Very High Very High Very High
Disorder Of Lipid Metabolism 63 98.56 Very High Very High Very High
Obesity 153 98.00 Very High Very High Very High
INFLAMMATION 12 89.84 High High
Atherosclerosis 21 83.92 Quite High
Cardiovascular Disease 12 60.80 Quite High
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Overweight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that apoA-I strongly stimulates apoE secretion, suggesting that in pathological conditions, such as obesity, the combination of low HDL-c levels (carrying apoA-I) and oxidative stress contributes to a major reduction in adipocyte apoE secretion.
Negative_regulation (reduction) of Localization (secretion) of apoE in adipocyte associated with stress, obesity and disorder of lipid metabolism
1) Confidence 0.56 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 1.05 Pain Relevance 0.11
Furthermore, brefeldin A (BFA), an intracellular trafficking inhibitor, reduces basal cholesterol and apoE secretion, but does not modify induction by apoA-I.
Negative_regulation (reduces) of Localization (secretion) of apoE in BFA
2) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2917427 Disease Relevance 0.87 Pain Relevance 0
Brefeldin A inhibits basal apoE secretion but not apoA-I induced apoE secretion
Negative_regulation (inhibits) of Localization (secretion) of apoE
3) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.30 Pain Relevance 0

General Comments

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